Lung Cancer

Question 1

Management of small cell lung cancer

Answer 1

. Chemotherapy (highly sensitive)
. Radiotherapy if SVC obstruction
. Surgery contraindicated

Question 2

Pt with lung cancer, the tumor is 4 cm, with ipsilateral mediastinal LN involvement and no metastasis.
What is his TNM STAGING

Answer 2

T2 N2 M0

Question 3

Pt with lung cancer, the tumor is 6 cm, and ipsilateral subcarinal LN are involved with no distant metastasis.
What is his TNM staging?

Answer 3

T3 N2 M0

Question 4

How to differentiate between primary and secondary lunf tumors?

Answer 4

By IHC,
If TTF-1 staining is positive, then its primary.

Question 5

Carcinoid syndrome is a lung tumor and is associated with increased secretion of…..

Answer 5

Serotonin (5HT)

Question 6

Malignant mesothelioma occurs mainly due to exposure to…..

Answer 6

Asbestos

Question 7

Malignant mesothelioma is associated with 2 genetic mutations, they are… And….

Answer 7

P16 and NF2

Question 8

How to differentiate between mesothelioma and pulmonary adenocarcinoma

Answer 8

By IHC
1.lung cancer is positive for TTF stains
2. Calretinin stain
*diffuse positivity: malignant mesothelioma
* focal positivity: adenocarcinoma