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LUNG LUNG > Lung cancer > Flashcards

Lung cancer Flashcards

1
Q

SCLC high yield

A

Agressive
Sensitive to chemotherapy
Smoking
Surgery is not commonly used

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2
Q

Which patients with NSCLC are candidates for surgical resection

A

Patient diagnosed in early stages (Until stage IIIA)

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3
Q

Which lung cancer form is the most common in women?

A

Adenocarcinoma

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4
Q

Adenocarcinoma is frequently (location)

A

Peripheral

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5
Q

Squmous cell carcinoma is more often found in which population?

A

Smokers

men

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6
Q

T1 stage

A

Tumor < 3 cm

Not involving main bronchus

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7
Q

T2 stage

A

Tumor > 3 cm
or
Involving main bronchus

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8
Q

T3 stage

A

Tumor into the chest wall/diaphragm but nor beyond carina or mediastinum

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9
Q

T4 stage

A

Tumor into the carina and/or mediastinal structures, heart, great vessels

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10
Q

N0

A

No lymph node involvement

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11
Q

N1

A

Ipsilateral peribronchial or hilar nodes

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12
Q

N2

A

Ipsilateral mediastinal or subcranial nodes

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13
Q

N3

A

Contralateral mediastinal/Hilar, supraclavicular, bilateral or scalenus lymph node bil.

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14
Q

M0

A

No metastasis

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15
Q

M1

A

Distant metastasis (Beyond regional lymph nodes)

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16
Q

SCLS stage I-III first line of treatment

A

Ciplatin/ Carboplatin + Etoposide
Chemotherapy 6 cycles
Thoracic radiotherapy is given after the 3rd course

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17
Q

SCLS stage IV second line of treatment

A

Topotecan OR
Epirubicine-Cyclophosphamis-Vincristine
4 cycles

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18
Q

NSCLC surgucal treatment is for what stages

A

IA-IIIA

19
Q

What is Adjuvent chemotherapy?

A

After surgery to improve the outcome

For patients with stage IB-IIIA

20
Q

What is Neo-Adjuvent chemotherapy?

A

Before surgery to make the lesion resecable (IIIA)

21
Q

What does Palliative mean?

A

Relieving pain without dealing with the cause of the condition

22
Q

NSCLC- Contraindication for surgery

A 
Old
MI in past 3 months
Arrhythmias
Pulmonary HTN
Severe COPD
23
Q

NSCLC stages IIIB-IV chemotherapy is based on what?

A

Platinum

24
Q

When will we give second/third line of treatment?

A

Id first line fails
or
Progression occurs within 6 months after previous line

25
Q

second/third line of treatment drugs

A

Docetaxel

Pemetrexed monotherapy

26
Q

Chemotherapy MOA

A

Kills cells that divide rapidly

27
Q

Chemotherapy side effects

A

Bone marrow- Myelosuppression
GI- Nausea, Vomiting
Hair

Fatigue
Neuropathy

28
Q

Molecular targeted therapy in locally advanced IIIB and metastatis IV adenocarcinoma

A

Bevacizumab- VEGF inhibitor (With chemotherapy)

Gefitinib, Erlotinib- EGFR Antag. (Tyrosine-Kinase inhibitor)

29
Q

Bevacizumab- VEGF inhibitor side effects

A

Bleeding
Haemoptysis
HTN

30
Q

VEGF inhibitor drug name

A

Bevacizumab

31
Q

What is ALK+

A

Anaplastic Lymphoma Kinase +

Cancer may grow more quickly

32
Q

ALK+ occurs in what % in NSCLC?

A

5%

33
Q

NSCLC types and %

A

Adenocarcinoma 40%
SCC 25-30%
LCC 10-15%
Others 15-25%

34
Q

SCLC is usually treated with what and Why?

A

Chemotherapy

High sensitivity

35
Q

Origin of SCLS

A

Neuroendocrine cells

36
Q

TNM staging

A

T 1-4
N 0-3
M 0/1

37
Q

Adenocarcinoma can manifest in what syndrome and why?

A

Horner syndorme

Pancoast tumor that compress nearby vessels and nerves- Brachial plexus, Cervial symp. chain

38
Q

Horner syndrome

A

Ptosis
Miosis
Anhydrosis

39
Q

Which hormone can be released by SCC

A

Parathyroid hormone

40
Q

Symptoms in case of carcinoid lung cancer

A

Serotonin/Carcinoid syndrome

Serotonin induced valvular fibrosis and bronchoconstriction, Flushing

41
Q

Most common metastasis sites of lung cancer

A 
Bone
Liver
Lymph
Adrenal
Brain
42
Q

What causes hoarseness?

A

Recurrent laryngeal nerve palsy

43
Q

If the cancer lesion is present in the middle of the lung, how can we take biopsy?

A

VATS

Video Assisted Thoracic Surgery

LUNG LUNG (13 decks)

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