Asthma

Question 1

Definition of Asthma

Answer 1

Chronic inflammatory disorder of the airway

Aiwray hyperresponsiveness

Question 2

Asthma inflammatory cells are composed of

Answer 2

Mast cells
Eosinophils
Lymphocytes

Question 3

Bronchoconstriction is caused by

Answer 3

Histamine
Leukotrienes
Prostaglandins

Question 4

Besides Bronchoconstriction, what else is involved in asthma?

Answer 4

Edema formation
Mucus hypersecretion
Structual changes (Hypertrophy and hyperplasia)
Tissue fibrosis

Question 5

Astham possible ways to classified (3)

Answer 5

Severity
Control level
Etiology

Question 6

Asthma diagnosis

Answer 6

History
Lung function
Airway responsiveness
Allergic status

Question 7

Asthma symptoms

Answer 7

Wheezing
Coughing
Tight chest
Dyspnea
Sputum increases

Question 8

Describe what is wheezing

Answer 8

Intermittent, prolonged expiration

Question 9

What do we measure durring lung function tests?

Answer 9

Spirometry
PEF
Body plethysmography
Bronchial challenge
Exercise challenge

Question 10

Does decrease FEV1 proves the diagnosis of asthma?

Answer 10

No

Question 11

PEF normal renge

Answer 11

400-600 L/min

Question 12

Asthma patient PEF

Answer 12

200-400 L/min

Question 13

After methacholine, what would we expect to see in asthma patient FEV1?

Answer 13

A larger fail than in healthy person

Increase sensitivity

Question 14

Allergy test in asthma examples:

Answer 14

Skin prick test
Bronchial challenge test
IgE levels
Histamine levels

Question 15

What are the Pro’s of inhaled drugs?

Answer 15

Rapid onset
Less amount
Better tolerated

Question 16

Bronchodilators in the treatment of asthma? (3 main groups)

Answer 16

SABA
Muscarinic antagonists
Theophyllines (IV)

Question 17

Action of B2 Agonist can last how long

Answer 17

4-6 h

Question 18

Examples for B2 agonists

Answer 18

Salbutamol
Terbutaline
Fenoterol

Question 19

Inhaled steroids examples

Answer 19

Beclomrtasone
Budesonide
Fluticasone
Ciclesonide

Question 20

Zileuton is an example for what kind of drug?

Answer 20

5-LO inhibitor

Leukotriene modifier

Question 21

CycLT1-R-Antagonists examples (3)

Answer 21

Montelukast (Singulair)
Pranlukast
Zafirlukast

Question 22

Anti IgE drug

Answer 22

Omalizumab

Question 23

How many stepwise treatment steps are there for asthma?

Answer 23

5

Question 24

Drugs for each step

Answer 24

1- As needed SABA
2- As needed SABA, Low dose ICS
3- As needed SABA, LD ICS+LABA
4- As needed SABA, MD ICS+LABA
5- As needed SABA, Oral glucocorticosteroids