Lung CA

Question 1

Most common type of lung cancer

Answer 1

Adenocarcinoma

Question 2

Neuroendocrine markers that distinguishes small cell lung CA from nonsmall cell lung CA

Answer 2

CD56, NCAM, synaptophysin, chromogranin

Question 3

Type of lung cancer most commonly associated with paraneoplastic syndromes

Answer 3

Small cell lung cancer

Question 4

Most common type of lung cancer among never smokers

Answer 4

Adenocarcinoma

Question 5

Type of lung cancer most commonly associated with smoking

Answer 5

Squamous cell lung cancer and small cell lung cancer

Question 6

Most common type of lung adenocarcinoma

Answer 6

Invasive non-mucinous adenocarcinoma

Question 7

Favorable subtype of invasive non-mucinous adenocarcinoma

Answer 7

Lepidic

Question 8

Indicator of a primary lung adenocarcinoma in the absence of thyroid cancer

Answer 8

TTF-1

Question 9

IHC differentiation between lung adenocarcinoma and lung squamous cell carcinoma

Answer 9

Lung adenocarcinoma: positive for TTF-1, Nap-A, CK7

Lung squamous cell carcinoma: positive for p63

Question 10

Most frequently activated gene in both small cell and nonsmall cell lung cancer

Answer 10

MYC

Question 11

Local extension of a tumor growing in the apex of the lung, 8th cervical + 1st and 2nd thoracic nerve involvement, shoulder pain radiating in the ulnar distribution, with radiologic destruction of the 1st and 2nd ribs

Answer 11

Pancoast’s (or superior sulcus tumor) syndrome

Question 12

Centrally located type of lung cancer

Answer 12

Small cell lung cancer, squamous cell lung cancer

Question 13

Peripherally located type of lung cancer

Answer 13

Lung adenocarcinoma, large cell lung cancer

Question 14

Nonsmall cell lung cancer staging

Answer 14

T1: 2-3cm
T2: 3-7cm
T3: >7cm, outside lung but until pericardium, 2 nodules of same lobe
T4: outside lung, 2 nodules different lobes

N1: peribronchial/hilar/intrapulmonary
N2: mediastinal/subcarinal
N3: contralateral side, outside mediastinum

Stage Ia: TINOMO
Stage Ib: T2aNOMO

Question 15

Small cell lung cancer staging

Answer 15

Limited-stage disease vs extensive-stage disease

Question 16

Treatment of choice for stage I-III, N0-1

Answer 16

Surgical resection

With adjuvant chemotherapy for stage II and III

Question 17

Treatment of choice for N2-N3

Answer 17

Chemotherapy plus radiotherapy

Question 18

First line chemo for nonsquamous lung cancer

Answer 18

Cisplatin + pemetrexed

Question 19

First line chemo for squamous lung cancer

Answer 19

Cisplatin + gemcitabine

Question 20

First line chemo for nonsquamous nonsmall cell lung cancer

Answer 20

Carboplatin + paclitaxel + bevacizumab

Question 21

First line chemo for small cell lung cancer

Answer 21

Cisplatin/carboplatin + etoposide

Question 22

The only FDA-approved agent as 2nd line chemo for small cell lung cancer

Answer 22

Topotecan