Breast CA

Question 1

Effect of chronic low-dose aspirin to incidence of breast cancer

Answer 1

Decreased

Question 2

If with equivocal or nonsuspicious lesion on PE of premenopausal women

Answer 2

Reexamine in 2-4wks during follicular phase of menstrual cycle (days 5-7)

Question 3

If with mammographic lesion but not palpable, low index of suspicion

Answer 3

Repeat mammogram after 3-6 months

Question 4

If with mammographic lesion, looks malignant

Answer 4

Excision biopsy

Question 5

Majority of benign breast masses

Answer 5

Fibrocyctic disease

Question 6

Breast cancer staging

Answer 6

T1: 0.5-2cm
T2: 2-5cm
T3: > 5cm
T4: extension to chest wall, inflammation, satellite lesions, ulcerations

N1: 1-3 axillary LN and/or microscopic internal mammary LN
N2: 4-9 axillary LN or clinically apparent internal mammary LN without axillary
N3: >/= 10 axillary LN or infraclavicular LN or clinically apparent ipsilateral internal mammary LN + >/= 1 axillary LN

Stage I: T1N0M0
Stage IIa: T2N0M0
Stage IIb: T3N0M0
Stage IIIb: T4
Stage IIIc: N3

Question 7

Subtype of breast cancer likely to respond to endocrine therapy

Answer 7

Luminal A

Question 8

Triple negative subtype of breast cancer

Answer 8

Basal

Question 9

Subtype of breast cancer where BRCA mutations fall into

Answer 9

Basal

Question 10

Most important prognostic variable

Answer 10

Tumor stage

Question 11

First choice chemo for metastatic breast cancer

Answer 11

Aromatase inhibitors

Question 12

Treatment if with overexpression of erbB2 or her-2/neu

Answer 12

Trastuzumab + paclitaxel

Question 13

Treatment if triple negative subtype

Answer 13

Platinum-based

Question 14

Treatment for early stage premenopausal women

Answer 14

Adjuvant multidrug chemo followed by endocrine therapy

Question 15

Considered as a premalignant breast lesion

Answer 15

Lobular neoplasia