lung abscess Flashcards
definition
local suppurative necrosis in lung associated with cavity formation containing necrotic debris/fluid.
etiology
- Bacteria - Pseudomonas aeruginosa, Klebsiella PN, Staphylococcus aureus, Streptococcal PN, Nocardia spp, Haemophilus influenza.
- Nonbacterial pathogens e.g. parasites (Paragonimus, Entamoeba), fungi (e.g. Aspergillus, Cryptococcus, Histoplasma, Blastomyces) & Mycobacterium
- Decrease immunized patients,alcoholic.
- As an outcome of pneumonia and complicated bronchiectasis, septic embolism
- wounds to the chest, aspiration of foreign bodies and after operation on the upper airwys.
- lung infarction or presence tumour.
- Way of spreading - lymphogenic, hematogenic and contact
classification
- Acc to localization – L/R lung/both sides
- Acc to etiology :
- 1‘ abscess – infectious origin, caused by aspiration of pneumonia in healthy host
- 2‘ caused by preexisting conditn (e.g. obstructn), spread fr extrapulm site, bronchiectasis immunocompromised state. - Acc to duration :
- Acute: < 6 mths, abscess has thin wall
- Chronic: > 6 months, has capsule with pyogenic membrane and fluid - Periods:
- formation of abscess; it continues 10-12 days
- opening of the purulent abscess into the bronchus
Criteria for 1‘ & 2‘:
- devmt of destruction of lung tissue – intoxication syndrome
- no (+ve) dynamics in clinical pic
- no effects from treatment
pathogenesis
- immune insufficiency patient
- aspirated material settles in distal bronchial system and develops localized pneumonitis
- Within 24-48 hours, a large area of inflammation results, consisting of exudate, blood, and necrotic lung tissue. The abscess frequently connects with a bronchus and partially empties
- After pyogenic pneumonitis develops, liquefactive necrosis occur secondary to bacterial proliferation and inflammatory reaction to produce acute abscess
- As the liquefied necrotic material empties through the draining bronchus, a necrotic cavity contain air-fluid level is created
- infection may extend into pleural space and produce an empyema without rupture of the abscess cavity
- infectious process can extend to the hilar and mediastinal lymph nodes, and may become purulent.
clinical picture
- Formation of abscess (10-12 days)
- Intoxication syndrome, Pain syndrome
- Cough with little or no sputum
- Infiltration of lung tissue, Dyspnea, General indisposition
Objective examination
- Vocal fremitus increase at the place of infection
- Infiltration syndrome – bronchial breathing
- diminished vesicular or bronchial breathing, harsh with dry rales (superficial)
- In deep abscess or small size, results of objective examination not changed
- Opening of purulent abscess into bronchus
- ↓ Intoxication syndrome (↓ T‘C & chills, ↓ weakness, arthralgia, myalgia↓)
- Ptt‘s condition improve. slight dyspnea, Pain in the chest
- Infiltration of lung tissue syndrome
- full mouthed sputum (~ 500ml) – depends on size of abscess
- Severe cough with offensive purulent sputum (―full mouth‖): on standing separates into 3 layers: mucous, serous and purulent (from 200 ml to 1-2 L/day)
Objective examination
- dull tympanic sound
- Auscultation: if drainage of abscess (road) & cavity > 3 cm (large abscess) – amphoric breathing
- Additional sounds: small bubbling rales – inflammatory changes/pneumonia
- Unilateral thoracic lagging(affected side)
- VF – increased
- Percussion: tympanic / metallic sound; crackled - pot sound
- Auscultn: bronchial (amphoric / cavernous) breathing; resonant moist rales; gutta cadens (falling – drop sound)
main syndrome
- Infiltration Syndrome
- asymmetrical movement of chest in respiration
- dull sound on percussion - Intoxication Syndrome
- fever
- low appetite
- weakness
- myalgia
- arthralgia
- loss weight - Evacuation Syndrome
- decrease in temperature
- absent arthralgia/myalgia
- normal appetite
- improvement of condition of patient
investigation
- Blood cultures – neurophilic leucocytosis, shift to the left, increased ESR,
- Biochemical
- increase protein inflammation (C-reactive protein, seromucous)
- decrease albumin - Sputum exam :
- 1st stage – not specific
- 2nd stage – presence of 3 layers (mucous, serous, purulent), Elastic fibers, Leucocytes and erythrocytes. Dittrich‘s plugs - Chest Xray
- 1st stage – signs of infiltration, > intensive in central part & < intensive in periphery
- 2nd stage – cavity with air-fluid level - Bronchoscopy : differential Dx with tumor, TB. may evacuate fluid if abscess is near large bronchi. bronchitis detection
- CT scan –abscess walls well defined margin, localization, size, form
- Specimen obtained by transtracheal aspiration, bronchoscopy or percutaneous transthoracic aspiration with ultrasound guidance
treatment
- 1st stage : intensive antibiotic therapy – combi of 3 AB
- Penicillins/Cephalosporins for G(+)
- Metronidazole
- Aminoglycosides, fluoroquinolones.
Symptomatic treatment - expectorants and broncholytics. Detoxification therapy by infusion therapy- glucose, Ringer‘s solution, Vits B1, 6, C, - 2nd stage
- mucolytics, expectorants
- increase drainage – intensive Atbs & detoxification.
Not based on stage:
- Immunocorrection therapy
- Bed rest
- Antibiotics and sulpha drugs – penicillin, streptomycin given with tetracycline.
- Adequate draining, emptying of the cavity.
- Surgical treatment given in a month
Indications for surgical treatment
Indications for surgical treatment
- Destruction of wall of abscess with massive hemorrhage
- Septicemia
- Multiple abscesses
- Absent effect from antibiotic therapy
- wide spread development of process
- Conditions lead to amyloidosis of other internal oragans e.g. kidneys