LUNCHBOX, 2023

Question 1

What was the question of the Lunchbox trial?

Answer 1

Does the sequence of RT and chemo matter in advanced endometrial cancer?

Question 2

Type of study in Lunchbox?

Answer 2

RCT - Cis/EBRT > C/T x 4C; C/T x 3C - EBRT - C/T x 3C

Question 3

Inclusion criteria

Answer 3

n=48; Stage III or IV or Stage I or II w/serous or clear cell

Question 4

Results of the LUNCHBOX trial?

Answer 4

3yr-RFS: 85.7 vs.73.4%

3yr-OS: 88.4 cs. 80.9%
Closed due to futility analysis

Question 5

What is futility analysis?

Answer 5

Interim analysis for lack of benefit, use the patients recruited up to a specific time point to make statistical assumptions. about the final outcome of the study