GOG 122, 2006

Question 1

Study question of GOG 122?

Answer 1

To compare whole-abdominal irradiation and chemotherapy in women with stage III or IV endometrial carcinoma

Question 2

Inclusion criteria of GOG 122?

Answer 2

Stage III or IV any histology, s/p surgical staging and <2 cm residual tumor

Question 3

Type of study

Answer 3

RCT

Question 4

Intervention of GOG 122 (experimental arm?)

Answer 4

Whole abdominal irradiation (WBI)
(30 Gy in 20 daily fractions plus 15 Gy boost)

Question 5

Control arm of GOG 122?

Answer 5

Doxorubicin 60mg/m2 and cisplatin 50 mg/m2 every 3 weeks for 7 cycles, followed by one cycle of cisplatin.

Question 6

Results of GOG 122?

Answer 6

Chemo SS improved PFS and OS r/t WAI. Toxicity more in chemo.