GOG 258, 2019

Question 1

What was the study question in 258?

Answer 1

Evaluated the use of chemoRT vs chemo alone in locally advanced endometrial cancer

Question 2

What type of study was GOG 258?

Answer 2

RCT

Question 3

Arms of GOG 258?

Answer 3

6 cycles carbo/taxol vs chemoRT with cisp f/b 4C carboplatin and paclitaxel

Question 4

Inclusion criteria for GOG 258?

Answer 4

Stage III or IVA, surgically staged (<8 weeks), optional P- and PA- nodes, or Stage I or II clear cell or serous with +ve washings

Question 5

Conclusion of GOG 258?

Answer 5

PFS or OS were not improved with chemoRT vs chemo alone

ChemoRT had less vaginal, pelvic and PA recurrence

Chemo alone with less distant occurrence

Chemo alone – more patients completed regimen