LTRA Flashcards
1
Q
MoA
A
Blocks action of leukotriene on cysteinyl leukotriene receptor in lungs and bronchi.
Reduces bronchoconstriction + inflammation
2
Q
Examples
A
Montelukast
Zafirlukast
3
Q
When are they used?
A
Chronic asthma
Symptomatic relief of hayfever in asthma
4
Q
Side effects
A
Churg Strauss syndrome
Hepatotoxicity (zafirlukast)
5
Q
Hepatotoxicty
A
Zariflukast
Counsel patients to report symptoms
6
Q
Churg strauss syndrome
A
Occurs on withdrawal/reduction of dose.
- Eosionophilia
- Vasculitic rash
- Worsening pulmonary symptoms
- Cardiac complications
- Peripheral neuropathy
