Lorazepam (Ativan) Flashcards
1
Q
pH
A
lipid souble
2
Q
E 1/2 Time
A
14 hrs
3
Q
Onset
A
30 mins: Slower than other BZDs
4
Q
Peak
A
IV: 20 - 30 mins
5
Q
Metabolism
A
Not entirely dependent on hepatic enzymes; safer to use in liver failure pts. Metabolized to inactive metabolites Requires: polythylene glycol to make water soluble
6
Q
Clearance
A
Metabolic clearance: 5X slower than Midazolam
7
Q
CNS
A
Less CNS effects; less lipid solubility, otherwise similar to other BZDs
8
Q
Resp
A
Same as general benzo effects: Slow; shallow
9
Q
CV
A
Same as general benzo effects
10
Q
Post-Op Dose
A
IV: 1 - 4 mg *perferred over other BZDs Post-Op
