Flumazenil (Romazicon) Flashcards
1
Q
E 1/2 Time
A
30 - 60 mins
2
Q
Onset
A
Reversal within 2 mins
3
Q
Metabolism
A
Hepatic microsomal enzymes; inactive metabolites; NO side effects
4
Q
Clearance
A
Cleared by kidneys
5
Q
CNS
A
Contraindicated: In pts using antiepileptic drugs (AEDs); Can precipitate seizures
6
Q
Resp
A
Will increase MAC requirements (Benzos decrease volatile requirements)
7
Q
CV
A
None
8
Q
Dose
A
- Initial dose: IV: 0.2 mg; repeat 0.1 mg q 1 min to total 1 mg;
- 0.3 - 0.6 mg to reverse sedation;
- 0.5 - 1.0 mg complete reversal
9
Q
Post-Op GTT
A
Continuous Infusion: IV gtt: 0.1 - 0.4 mg/hr
