Diazepam (Valium) Flashcards
1
Q
pH
A
6.6 - 6.9 (lipid soluble)
2
Q
E 1/2 Time
A
20 - 40 hrs
3
Q
Onset
A
1 - 5 mins
4
Q
Peak
A
Peds: 15 -30 mins
Adults: 1 hr
5
Q
Metabolism
A
CYP3A; metabolized to active metabolites (desmethyldiazepam, temazepam, 2ndly to oxazepam); Inhibit CYP450 enzymes: Increase conc. of Cimetidine, Fentanyl, CCBs. Requires: polythylene glycol to make water soluble
6
Q
Clearance
A
- Hepatic metabolism;
- metabolites cleared by kidneys: 10X slower than Midazolam
7
Q
CNS
A
- Anticonvulsant; #For any type of seizure.
- CAN produce isoelectric EEG
8
Q
Resp
A
Minimal effect on ventilation. Surgical stimulation negates respiratory any depression
9
Q
CV
A
Minor decrease in BP, CO, SVR (even w/ induction dose)
10
Q
Induction Dose
A
- IV: 0.5 - 1 mg/kg.
- Decrease 25-50% in elderly, liver dx, alcoholics, or w/ opioids
11
Q
Seizure Dose
A
IV: 0.1 mg/kg
