Loope of Henle

Question 1

What is the loope of henle lined by ?

Answer 1

Epithelial cells

Thick asending is cuboidal epithelial cells

Question 2

What protein does the descending loop of henle have ?

Answer 2

Aquaporin protein

Question 3

What do aquaporin proteins allow the transportation of and where?

Answer 3

Water to be filtered out of the descending loope of henle into the interstitium.

Question 4

What happens in the decedning loope of henle

Answer 4

At the start of the descending limn, the osmolality is 300 m0sm/L

The aquaporin proteins remove water into the interstitial fluid.

Therefore, the descending limb becomes concentrated at approximately 1200 m0sm/L.

Question 5

What happens in the THIN asending limb of henle ?

Answer 5

This ascending limb is impermeable to water!! NO WATER PASSES THROUGH BECAUSE IT HAS NO AQUAPORIN PROTEINS.

Instead it has NA+ and CL- channels that allows these ions to diffuse from the renal tubule into the intersitital fluid.

As we start to travel up the asending loop it starts to decrease in osmorlarity.

Question 6

What cell is the thick ascending limb lined with ?

Answer 6

Cuboidal epithelial cells

Question 7

What channel does the thick ascending limb of the loope of henle have ?

Answer 7

NA-K-2CL co transporters

Question 8

What happens in the thick ascending limb ?

Answer 8

NA-K-2CL transport into the cuboidal cell.

Here NA+/K+ ATPASE uses ATP to pump 3NA+ ions into the interstitial fluid in exchange for allowing 2K+ ions into the cuboidal cell

Finally, both CL- and K+ move from the cell into the interstitial by passive diffusion.

Question 9

Explain osmolarity in the thick asending loope of henle.

Answer 9

It is decreasing in osmolarity.

This is because sodium ions continue to move out.

Question 10

What is osmolarity refering to ?

Answer 10

Ion concentration

Question 11

Explain the osmolarity throughout the loop of henle

Answer 11