Long term potentiation Flashcards
What is Hebb’s rule?
if a synapse is repeatedly active at the same time that the postsynaptic neuron fires, there will be changes in either the structure or the chemistry of the synapse that STRENGTHENS it
What animal was involved in the 1966 experiment of LTP in the hippocampus?
rabbit
Associative LTP is demonstrated when a _____ synapse is ______ as a result of its pairing with the firing of a _____ synapse
weak, strengthened, strong
In terms of LTP, stimuli must be delivered at a _____ rate
high
How long can LTP last?
months, days, years
LTP occurs in?
hippocampus
LTP increases the number of….
post synaptic receptors (AMPA)
AMPA receptors are activated by?
glutamate
When the receptors in the post synaptic cell are more ______ and ______ there is an increased possibility of the post syn cell firing when glutamate is released
sensitive, numerous
the LTP process is dependent on the ____ glutamate receptor, if it is blocked with an antagonist, it prevents the movement and emergence of _____ receptors
NMDA, AMPA
______ synapses are the precursors to formation of new synapses
perforated
What 2 things are needed to move magnesium?
glutamate and depolarization
What is needed for the creation of new AMPA receptors
protein synthesis
Where are some places in the brain besides the hippocampus that LTP can occur?
prefrontal cortex, piriform cortex, entorhinal cortex, thalamus, amygdala, visual cortex, motor cortex
In EE animals, what type of cells are found to be increased?
glial cells
