Localization of ANS and Hypothalamic Disorders

Question 1

Consequences of lesion in Anterior hypothalamus.

Answer 1

"parasympathetic area" 
Hyperthermia
Insomnia
Diabetes insipidus
Emaciation

Question 2

Consequences of lesion in Lateral hypothalamus.

Answer 2

“drinking center”
Adipsia
Emaciation
Apathy

Question 3

Consequences of lesion in Medial hypothalamus.

Answer 3

hyperdipsia
Diabetes insipidus
Syndrom of inappropriate antidiuretic hormone secretion 
Obesity 
Rage
Amnesia 
Dwarfism 
Ipsilateral Horner syndrome

Question 4

Consequences of lesion in Posterior hypothalamus.

Answer 4

"sympathetic area" 
Hypothermia - poikilothermia
Hypersomnia
Coma
Narcolepsy 
Apathy
Ipsilateral Horner syndrome

Question 5

Suprachiasmatic nucleus function?

Lesion?

Answer 5

Function: regulates circadian rhythm
Lesion: causes insomnia

Question 6

Anterior nucleus function?

Lesion?

Answer 6

Function: to dissipate heat
Lesion: causes hyperthermia
Commonly stimulated by endogenous pyrogens (IL-1 and PGE2) when a person is ill –> fever

Question 7

Medial hypothalamus function?

Lesion?

Answer 7

Regulates feeding behavior

Lesion: causes obesity due to overeating

Question 8

Prader Willi Syndrome

Answer 8

Chromosomal deletion of 15q11-13
Inherited through father
Hypothalamic dysfunction includes hyperphagia with eventual obesity; narcolepsy; short stature