Liver Phys Flashcards
What do secreted bile acids do in liver
Make osmotic gradient for water and electrolytes
What do returning bile acids do ?
Inhibit synthesis of new bile acids
2 main bile acids
Chalk acid and Chenodeoxycholic acid
Least lipid soluble bile acid
Cholic acid
What do micelles allow bile acids to do
Become emulsifying agents
What’s on the outside of liver micelles? inside?
Bile acids and bile salts on outside
Cholesterol and phospholipids in inside
What type of bile acids are most likely to pass through cell membranes
Lipid soluble
What allows for exchange b/w blood and bile in liver
countercurrent blood flow
Max rate of bile acid synthesis
3-5 grams per day
How are bile acids secreted from liver
In Na dependent process
sets up osmotic gradient for water and electrolytes
How does bilirubin get to the liver
By being conjugated to albumin
is insoluble in water
What happens when bilirubin gets to the liver
Gets conjugate to glucuronic acid to make bilirubin glucuronide
What does bacteria turn bilirubin to in colon
Uroblinogen
What concentrates the bile in the liver
Na and Cl are absorbed
What makes gallbladder bile isosmotic to plasma
It’s bound to micelles
What relaxes the sphincter of oddi
Ach and CCK
