Liver Part 1 Flashcards
What are the two main detoxifying pathways of the liver?
cytP450
glutathione
What are 5 responses seen in liver disease?
- Degeneration and intracellular accumulation
- necrosis and apoptosis
- inflammation
- regeneration
- fibrosis
Degeneration and intracellular accumulation
- swelling hepatocytes
- ballooning degeneration
What are 3 types of toxic intracellular deposition?
hemochromatosis
wilsons disease (copper)
steatosis
What types of cells are seen in iron deposition?
Kupfer cells and hepatocytes filled with granular brown deposits of hemosiderin
What type of cells are seen with necrosis and apoptosis?
councilman bodies:
- coalesced shrunken hepatocytes
- intense eosinophilic staining and fragmented nuclei
fibrosis
fibrous tissue formed in response to inflammation
- not usually reversible
- deposition of collagen
- scar tissue = cirrhosis
3 non hepatitis viruses that involve the liver?
- epstein-barr virus (EBV)
- cytomegalovirus
- yellow fever
Hep A
acute
fecal oral
Hep B
acute or chronic
cirrhosis
iv drug users
only DNA hep virus
What is the only DNA hep virus?
Hep B
What hep increases risk for developing hepatocellular carcinoma?
Hep B
Hep C
Hep C
acute or chronic IV drug users hepatocellular carcinoma cirrhosis chronic carrier (more likely than hep B)
1 cause of hep in US?
Hep C
Surpa infection?
get hep B, then hep D
