LIVER OVERVIEW

Question 1

The major organ of Metabolism

Answer 1

Liver

Question 2

All major pathways take place here

Answer 2

Liver

Question 3

Glucose will be utilized by what tissue of the Liver?

Answer 3

Peripheral tissue

Question 4

The major pathways concerned with the metabolism of glucose

Answer 4

Glycolysis
Gluconeogenesis
Glycogenolysis

Question 5

Major pathways in the liver

Answer 5

Glycolysis, gluconeogenesis, lipogenesis,

β-oxidation, citric acid cycle, ketogenesis,

lipoprotein metabolism, drug metabolism
(CYP450),

synthesis of bile salts, urea, uric
acid,

cholesterol, plasma proteins

Question 6

Main substrates in Liver metabolism

Answer 6

Nonesterified fatty acids (NEFA or free fatty
acids),
amino acids,
alcohol
lactate,
glycerol,
glucose (in fed state),
fructose,

Question 7

Major products exported in the liver

Answer 7

Glucose, triacylglycerol in VLDL, ketone
bodies, urea, uric acid, bile salts,
cholesterol, plasma proteins

Question 8

Special enzymes involved in metabolism in the liver

Answer 8

Glucokinase, glucose-6-phosphatase,
glycerol kinase, phosphoenolpyruvate
carboxykinase, fructokinase, arginase,
HMG-CoA synthase, HMG-CoA lyase,
alcohol dehydrogenase

Question 9

These cannot be used by the liver, hence will be transported to other organs needing it the most

Answer 9

Ketone bodies

Question 10

This is an integral enzyme for carbohydrate metabolism found in the liver

Answer 10

Glucokinase