Liver Metab Flashcards
The lobules are
The functional unit of the liver
The functional unit of the liver is
Lobules
Kupffer cells??
The phagocytoses pathogens and degrade them
Heme of heamoglobin is broken down first to ————- by ————-
Biliverdin by heam oxygenase
Unconjugated bilirubin is produced by
Billieverdin ——————-> bilirubin
Billiverdin reductase
Billiverdin reduced to bilirubin by Billiverdin reductase
What do you understand by uncongugated bilirubin
Bilirubin which is insoluble in water but soluble in lipid
What receptor takes up bilirubin in the liver
Lingand Y
Bilirubin is conjugated at where in the hepatocyte
Smooth ER
endoplasmic reticulum
Bilirubin is conjugated by
Adding glucoronic acid to it
Conjugation of bilirubin is carried out by what enzyme
Uridine diphosphate transferase 1
Deficiency of Uridine diphosphate transferase 1 is called
Criggler najjar syndrome
Criggler najjar syndrome is
Deficiency of Uridine diphosphate transferase 1
Urobillinogen???
Bilirubin is converted to urobillinogen by GIT flora
Bilirubin in stool is called
Stecobillinogen
What causes the browness of stool
Stercobillin
Jaundice is
Increased level of bilirubin in the body > 50
Dubin Johnson syndrome is
Defect in the excretion of conjugated bilirubin into the bile canaculli
What stain is used to differentiate Criggler syndrome and dubin johnson syndrome
Lipofusin
Gallstones is majorly made up of
Cholesterol bilirubin calcium and mucoproteins
What stone appears mulberry like
Cholesterol stone
What stone is radio opaque and why
Mixed stone
Cause it has enough calcium in it
Cholecystectomy is
Surgical removal of gallbladder
