Liver Metab

Question 1

The lobules are

Answer 1

The functional unit of the liver

Question 2

The functional unit of the liver is

Answer 2

Lobules

Question 3

Kupffer cells??

Answer 3

The phagocytoses pathogens and degrade them

Question 4

Heme of heamoglobin is broken down first to ————- by ————-

Answer 4

Biliverdin by heam oxygenase

Question 5

Unconjugated bilirubin is produced by

Answer 5

Billieverdin ——————-> bilirubin
Billiverdin reductase

Billiverdin reduced to bilirubin by Billiverdin reductase

Question 6

What do you understand by uncongugated bilirubin

Answer 6

Bilirubin which is insoluble in water but soluble in lipid

Question 7

What receptor takes up bilirubin in the liver

Answer 7

Lingand Y

Question 8

Bilirubin is conjugated at where in the hepatocyte

Answer 8

Smooth ER
endoplasmic reticulum

Question 9

Bilirubin is conjugated by

Answer 9

Adding glucoronic acid to it

Question 10

Conjugation of bilirubin is carried out by what enzyme

Answer 10

Uridine diphosphate transferase 1

Question 11

Deficiency of Uridine diphosphate transferase 1 is called

Answer 11

Criggler najjar syndrome

Question 12

Criggler najjar syndrome is

Answer 12

Deficiency of Uridine diphosphate transferase 1

Question 13

Urobillinogen???

Answer 13

Bilirubin is converted to urobillinogen by GIT flora

Question 14

Bilirubin in stool is called

Answer 14

Stecobillinogen

Question 15

What causes the browness of stool

Answer 15

Stercobillin

Question 16

Jaundice is

Answer 16

Increased level of bilirubin in the body > 50

Question 17

Dubin Johnson syndrome is

Answer 17

Defect in the excretion of conjugated bilirubin into the bile canaculli

Question 18

What stain is used to differentiate Criggler syndrome and dubin johnson syndrome

Answer 18

Lipofusin

Question 19

Gallstones is majorly made up of

Answer 19

Cholesterol bilirubin calcium and mucoproteins

Question 20

What stone appears mulberry like

Answer 20

Cholesterol stone

Question 21

What stone is radio opaque and why

Answer 21

Mixed stone
Cause it has enough calcium in it

Question 22

Cholecystectomy is

Answer 22

Surgical removal of gallbladder