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Phase 2a flashcards (Alec's) > Liver medications > Flashcards

Liver medications Flashcards

1
Q

What is the most common cause of acute liver failure in the UK?

A

Paracetamol overdose

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2
Q

What is used to grade the extent of hepatic encephalopathy?

A

West haven criteria

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3
Q

How is hepatic encephalopathy treated?

A

Lactulose

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4
Q

How are ascites treated?

A

Spironolactone

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5
Q

What is used to assess prognosis and treatment required for chronic liver failure?

A

Child pugh score

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6
Q

What are the stages of alcoholic liver disease?

A

Steatosis –> alcoholic hepatitis –> alcoholic cirrhosis

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7
Q

What is seen on biopsy of those with alcoholic liver cirrhosis?

A

Mallory cytoplasmic inclusion bodies

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8
Q

How is delirium tremens treated?

A

Chlordizepoxide

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9
Q

What are the stages of fatty liver disease?

A

Hepatosteatosis –> non alcoholic steatohepatitis –> fibrosis –> cirrhosis

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10
Q

What does HBcAb represent?

A

Exposure to HBV at some point

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11
Q

What does HBcIgM/G represent?

A
  • HBcIgM = acute infection
  • HBcIgG = chronic infection
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12
Q

Who is affected by type 1 vs 2 autoimmune hepatitis?

A
  • 1 = adult females
  • 2 = young females
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13
Q

What antibodies are associated with type 1 vs 2 autoimmune hepatitis?

A
  • 1 = ANA and ASMA
  • 2 = ALC-1 and ALKM-1
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14
Q

What is a blood marker for pancreatic cancer (and lots of other cancers)?

A

Ca19-9

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15
Q

Who is affected most by PBC?

A

Females (40-50)

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16
Q

Who is affected most by PSC?

A

Males (40-50)

17
Q

What is the serology of PBC vs PSC?

A
  • PBC = AMA
  • PSC = pANCA
18
Q

How is PBC vs PSC imaged?

A
  • PBC = USS
  • PSC = MRCP
19
Q

How is PBC vs PSC managed?

A
  • PBC = Ursedeoxycholic acid
  • PSC = conservative
20
Q

How is pruritus treated?

A

Cholestyramine

21
Q

What blood marker is more specific and sensitive to pancreatitis?

A

Lipase = more specific and sensitive

22
Q

What is a complication of pancreatitis?

A

Systemic inflammatory responce syndrome

23
Q

What medication can be given to stop oesophageal varices bleeding?

A

IV terlipressin

24
Q

What chromosome is affected in haemochromatosis?

A

Chromosome 6

25
Q

What chromosome is affected in Wilsons?

A

Chromosome 13

26
Q

What sign is seen in Wilsons disease?

A

Kayser fleischer rings

27
Q

How is Wilsons treated?

A

D-penicillamine

28
Q

What substance builds up in paracetamol overdose?

A

NAPQI

29
Q

What substance breaks down NAPQI?

A

Glutathione

30
Q

How is a paracetamol overdose treated?

A
  • Activated charcoal within 1 hour
  • N-acetyl cysteine
31
Q

What chromosome does A1ATD affect?

A

Chromosome 14

Phase 2a flashcards (Alec's) (13 decks)

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