Liver Function Tests

Question 1

Which two tests and key for intrehepatic measurements?

Answer 1

ALT

AST

Question 2

Which tests are key for a cholestatic picture

Answer 2

ALP

Bilirubin

Question 3

Which marker falls in hepatic decline?

Answer 3

Albumin

Question 4

Which test goes up in bone damage and pregnancy?

Answer 4

ALP

Question 5

Which test shows long term alcohol abuse?

Answer 5

GGT

Question 6

When does unconjugated bilirubin rise?

Answer 6

If there is an increase in haemolysis or a hepatic block

Question 7

When does conjugated bilirubin arise?

Answer 7

• Blockage in the biliary tree

Question 8

What would indicate an acute hepatic problem?

Answer 8

A huge rise in ALT x10+

Question 9

What would indicate a chronic hepatic problem

Answer 9

A rise in ALT x5

Question 10

What is the tumour marker for hepatic cancer?

Answer 10

AFP

Question 11

What would happen to the clotting test times in liver disease?

Answer 11

They would rise

PT (INR)

APTT

TT

Question 12

What test would you do for suspected haemochromotosis and what are the symptoms?

Answer 12

1. Arthritis
2. Liver disease
3. DM
4. Hyperpigmentation

FERRITIN

Question 13

What could cause an acute rise in ALT?

Answer 13

Hepatitis

Overdose (Paracetamol, toadstools)

ALD

Ischaemia

Trauma

Question 14

What could cause an chronic rise in ALT?

Answer 14

Hep B and C

ALD

Autoimmune

Haemochoromotosis

Fatty Liver

Question 15

What additional tests may you want to do when investigating liver function?

Answer 15

• Serology
• Antibodies
• MRI/CT