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Clinical Chemistry > Liver Function Test > Flashcards

Liver Function Test Flashcards

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1
Q

it is the CHIEF metabolic organ of the body?

A

liver

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2
Q

how mL of blood does liver RECEIVED per minute

A

15 mL

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3
Q

FUNCTIONS OF THE KIDNEY

A
  1. Synthetic function
  2. Conjugation function
  3. Detoxification and Drug metabolism
  4. Excretory and Secretory function
  5. Storage function
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4
Q

how many grams of ALBUMIN does a normal liver PRODUCE daily?

A

12 grams

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5
Q

how many BILIRUBIN is PRODUCED daily of a healthy adult?

A

200 - 300 mg

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6
Q

it is important for assessing NUTRITIONAL STATUS and presence of severe diseases involving LIVER, KIDNEY and BONE MARROW

A

total protein

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7
Q

Tests measuring the HEPATIC SYNTHETIC FUNCTION

A
  1. TOTAL PROTEIN
  2. PROTHROMBIN TIME

ALBUMIN

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8
Q

total protein Reference method but not routinely used

A

kjeldahl method

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9
Q

TOTAL PROTEIN

most widely used protein

A

biuret method

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10
Q

TOTAL PROTEIN

it has the HIGHEST ANALYTICAL SENSITIVITY

A

FOLIN CLOCALTEU (LOWRY) METHOD

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11
Q

TOTAL PROTEIN

reagent used in kjeldahl method

A

h2so4 (digesting agent)

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12
Q

TOTAL PROTEIN

reagent used in biuret method

A
  1. alkaline copper sulfate
  2. rochelle salt (NaK tartrate)
  3. NaOH and Potassium iodide
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13
Q

TOTAL PROTEIN

reagent used in folin clocalteu (lowry) method

A

phosphotungstic molybdic acid or phenol reagent

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14
Q

it is based on measurement of nitrogen content of protein

a. biuret method
b. folin clocalteu method
c. kjeldahl method

A

it is based on measurement of nitrogen content of protein

c. kjeldahl method

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15
Q

what is the equivalent 1 gram nitrogen to proteins?

a. 2.34 g
b. 6.54 g
c. 6. 64 g

A

what is the equivalent 1 gram nitrogen to proteins?

c. 6.54 g

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16
Q

end product of kjeldahl method?

A

ammonia

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17
Q

proteins absorbs light at what nm?

A

210 nm an 280 nm

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18
Q

migration of charged particles in an ELECTRIC FIELD

A

serum protein electrophoresis

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19
Q

Rheumatoid arthritis and malignancy would result to polyclonal gammopathy classified as?

A

chronic inflammation

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20
Q

the presence of SMALL SPIKES in BETA REGION is due to?

A

iron deficiency anemia

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21
Q

reagent used in SALT FRACTIONATION

A

SODUIM SULFATE SALT

22
Q

alternative test to chemical analysis of serum total proteins

a. spe
b. refractometry
c. salt fractionation

A

alternative test to chemical analysis of serum total proteins

b. refractometry

23
Q

globulin is insoluble in water but NOT in___________?’

a. dilute salt solution
b. sodium picric acid
c. NSS

A

globulin is insoluble in water but NOT in___________?’

a. dilute salt solution

24
Q

it is detection of proteins as little as 1ug

a. nihydrin
b. refractometry
c. coomassie brilliant blue dye

A

it is detection of proteins as little as 1ug

c. coomassie brilliant blue dye

25
Q

it is widely used for detection of peptides and amino acids after paper chromatography

A

nihydrin

26
Q

increased total protein, EXCEPT

A. malignancy
B. hepatic cirrhosis
C. multiple myeloma
d. walderstrom’s macroglobulinemia

A

increased total protein, EXCEPT

B. hepatic cirrhosis

27
Q

in ACUTE VIRAL or TOXIC HEPATITIS prolonged protime signifies?

A

massive cellular damage

28
Q

Low Total Protein + Low Albumin =

a. hepatic cirrhosis
b. nephrotic syndrome
c. both

A

Low Total Protein + Low Albumin =

c. both
hepatic cirrhosis and nephrotic syndrome

29
Q

DYES used for the measurement of albumin

A
  1. Bromcresol Green
  2. Methyl Orange (MO)
  3. Hydroxyazobenzene Benzoic acid ( HABA)
  4. Bromcresol Purple
30
Q

MOST COMMON USED DYE in measurement of albumin

A

bromcresol Green

c = g

31
Q

MOST SPECIFIC USED DYE in measurement of albumin

A

BROMCRESOL PURPLE

sPecific = PurPle

32
Q

it is a dye can be used in automated analyzers for determining serum albumin in parallel with Biuret reagent of total protein

a. bcg
b. bcp
c. haba
d. mo

A

bcg

g= gamit na gamit heehehe

33
Q
  • IT IS ASSOCIATED WITH EXCESS AMOUNT OF THERAPEUTIC DRUGS IN SERUM
  • IT IS THE PRESENCE OF ALBUMIN WITH UNUSUAL MOLECULAR CHARACTERISTICS IN THE BLOOD

A. analbuninemia
B. bisalbinunemia

A

b. bisalbinunemia

34
Q

if GLOBULIN is GREATER THAN albumin it is called INVERTED A/G RATION it is seen in

A
  1. Cirrhosis
  2. Multiple Myeloma
  3. Walderstorm’s macroglobilenemia
35
Q

it is the end product of hemoglobin metabolism

A

bilirubin

36
Q

it is formed from destruction of heme containing proteins such as myoglobin, catalase and cytochrome oxidase

A

bilirubin

37
Q

formula of delta bilirubin

A

tb - db + id = db

38
Q

CAUSE: failure of the bile to flow to the intestine/impaired bilirubin excretion

a. pre hepatic jaundice
b. post hepatic jaundice
c. hepatocellular combined jaundice

A

CAUSE: failure of the bile to flow to the intestine/impaired bilirubin excretion

b. post hepatic jaundice

39
Q

Bilirubin TRANSPORT deficit

a. Gilbert’s syndrome
b. Crigler- Najjar syndrome
c. Dubin Johnson syndrome

A

Bilirubin TRANSPORT deficit

a. Gilbert’s syndrome

40
Q

what are the methods of bilirubin assay

A
  1. Evelyn and Malloy Method

2. Jendrassik and Grof

41
Q

VAN DE BERG REACTION is diazotization of bilirubin to produce azobilirubun

a. Bilirubin assay
b. BSP dye excretion test

A

VAN DE BERG REACTION is diazotization of bilirubin to produce azobilirubun

a. Bilirubin assay

42
Q

BUFFER for jendrassik and grof?

A

sodium acetate

43
Q

coupling accelerator for evelyn and malloy method?

A

methanol

44
Q

Terminates the initial reaction in jendrassik and grof and destroys the excess diazo reagent?

a. sodium acetate
b. ascorbic acid
c. caffein sodium benzoate

A

Terminates the initial reaction in jendrassik and grof and destroys the excess diazo reagent?

b. ascorbic acid

45
Q

colorless end product of bilirubin metabolism

A

urobilinogen

46
Q

what are the specimen in urobilinogen?

A
  1. 2hr freshly collected urine

2. freshly collected stool

47
Q

method for urobilinogen

A

Ehrlich’s method (p-dimethyl aminobenzaldehyde reagent)

48
Q

what are the test for DETOXIFICATION FUNCTION?

A
  1. Enzyme Tests

2. Ammonia

49
Q

enzymes secreted in liver

A

G gt
O ct
LD

ALP
LAP
AMINOTRANSFERASES

5 NUCLEOTIDASE

liver is mahal so meaning its GOLD mapapaisip ka nalang san ka kukuha nang ganon mapapatitig ka nalang sa ALAPAAP.

tas tandaan nalang ung 5 nucleotidase

50
Q

is is released from METABOLIC REACTIONS that occur in skeletal muscle during exercise

A

ammonia

51
Q

preferred specimen in AMMONIA

a. arterial blood
b. venous blood

A

preferred specimen in AMMONIA

a. arterial blood

52
Q

common methods for Ammonia

a. erhlich’s method
b. kjehdahl method and biuret method
c. berthelot and glutamate dehydrogenase

A

common methods for Ammonia

c. berthelot and glutamate dehydrogenase

Clinical Chemistry (4 decks)

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