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lipid and lipoproteins Flashcards

1
Q

it helps to keep lipids in solution (solubililty) during circulation through the bloodstream

a. apolipoproteins
b. chylomicrons
c. lipoprotein

A

apolipoproteins

lipoprotein—- is a large macromolecule complexes of lipids

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2
Q

amphiphatic helix

a. structural motif of apolipoproteins
b. vit. e depends on amphi helix fior absorption
c. ability of proteins to bind to lipids

A

a&c

structural motif of apolipoprotein- amphiphatic helix—-> ability of proteins to bind to lipids

vit. e depends of CHYLOMICRONS for absorption

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3
Q

Beta lipoprotein

a. HDL
b. VLDL
c. LDL

A

LDL

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4
Q

pre beta lipoprotein

a. HDL
b. VLDL
c. LDL

A

vldl

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5
Q

alpha lipoprotein

a. hdl
b. vldl
c. ldl

A

hdl

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6
Q

LARGEST but LEAST DENSE

a. Hdl
b. CM
c. IDL

A

chylomicrons

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7
Q

smallest but most dense

a. hdl
b. ldl
c, cm

A

hdl

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8
Q

reverse cholesterol transport

a. hdl
b. vldl
c. ldl

A

hdl

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9
Q

nascent disk shaped particles

a. hdl
b. vldl
c. ldl

A

hdl

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10
Q

transport endogenous tag from the liver to the muscle, fat depots and tissues

a. cm
b. vldl
c. hdl
d. ldl

A

vldl

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11
Q

transport exogenous

a. cm
b. vldl
c. hdl
d. ldl

A

cm

ExCHY

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12
Q

HDL that transports effectively the lipids to the liver and more cardioactive

a. hdl1
b. hdl2
c. hdl3

A

HDL2

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13
Q

major end product from the catabolism of VLDL

a. hdl
b. ldl
c, cm

A

ldl

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14
Q

primary marker for CHD risk

a. cm
b. ldl
c. hdl
d. vldl

A

ldl

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15
Q

research method for LDL

a. abell kendal
b. ultracentrifugation
c, beta quantitation

A

beta quantitation

HDL cdc reference method:

ultacentrifugation
precipitation with heparin mncl
abell kendall

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16
Q

what are the MINOR LIPOPROTEINS

A
  1. INTERMEDIATED LIPOPROTEIN

2. LIPOPROTEIN A

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17
Q

it maintains the equilibrium of cholesterol in peripheral cells

a. CM
b. HDL
c. VLDL

A

HDL

it maintains the equilibrium of cholesterol in peripheral cells BY REVERSE CHOLESTEROL TRANSPORT PATHWAY

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18
Q

SYNTHESIZED by the Liver

a. hdl
b. vldl
c. ldl

A

LDL

LDL —> SYNTHESIZED in the liver
VLDL —> S E C R E T E D in the liver
{Vsec)
HDL —> P R O D U C E D in the Liver and Intestine {produH)

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19
Q

the MAJOR SOURCE OF CHOLESTEROL for tissue

a. HDL
b. LDL
c. LpA

A

LDL

it constitutes 50% ot the TOTAL LPP IN PLASMA

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20
Q

PRODUCT of VLDL catabolism

a. LDL
b. IDL
c. Lpp (a)

A

IDL

LDL —> END PRODUCT of VLDL catabolism

IDL —> PRODUCT of VLDL catabolism

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21
Q

VLDL REMNANT

a. LDL
b. IDL
c. Lpp (a)

A

IDL

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22
Q

CONVERTED TO LDL

a. VLDL
b. IDL
c. Lpp (a)

A

IDL

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23
Q

SUBCLASS OF LDL

a. VLDL
b. IDL
c. Lpp (a)

A

IDL

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24
Q

Defective clearance of Intermediate density lpp

a. type 1 hyperlipoproteinemia
b. type 3 hyperlipoproteinemia
c. tay sach’s disease

A

type 3 hyperlipoproteinemia

probably due to apo E-III

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25
SINKING lipoprotein a. HDL b. IDL c. Lpp (a)
lpp (A) A boat is SINKING
26
increased may indicate PREMATURE CORONARY HEART DISEASE A. LDL B. IDL C. LPP (a)
LPP (a) INCREASED LIPOPROTEIN A MAY INDICATE PREMATURE CHD AND STROKE
27
INDPENDENT RISK FACTOR OF ATHEROSCLEROSIS a. LDL b. IDL c. Lpp (a)
LPP (A)
28
SENSITIVITE and SPECIFIC indicator of CHOLESTASIS a. IDL B. LPP a c. LPP x
LPP X
29
it is an abnormal lpp that can be found in OBSTRUCTIVE JAUNDICE AND LCAT DEFICIENCY a. IDL B. BETA VLDL c. LPP X
LPP X
30
VLDL RICH IN CHOLESTEROL a. LDL B. BETA VLDL c. LPP x
BETA VLDL
31
it can be found in type 3 hyperlpp or dybetalpp a. IDL B. beta vldl c. LPP x
beta vldl IDL----> Defective clearance of Intermediate density lpp- type 3 hyperlpp- probably due to apo e - III b-VLDL------> it can be found in type 3 hyperlpp or dybetalpp
32
this sample occurs in non fasting samples of patient with HYPERLIPIDEMIA OR PATIENT RECEIVING TPN THERAPY a. hemolysed samples b. lipemic samples
lipemic sample
33
if NON FASTING SAMPLE is to be test, what test can be test? a. TAG and LDL-C b. TC and HDL-C c. TAG and TC
TOTAL CHOLESTEROL (TC) and HDL-C TAG and LDL-C are being measured, FASTING BECOMES A REQUIREMENT
34
REFERENCE METHOD for quantitation of lpp a. ultracentrifugation b. electophoresis c. chemical precipitation
ultracentrifugation
35
electtropheresis is expressed by whta unit?
svedverg
36
reagent used in electrophoresis a. sodium potassium solution b. potassium bromide solution c. potassium manganese solution
potassium bromide solution with density of 1.063
37
electrophoretic pattern
HDL, VLDL, LDL, CHYLOMICRON HDL - A lpha VLDL- PRE B LDL- B ETA
38
PREFERRED SUPPORTING MEDIUM FOR ELECTROPHORESIS a. edta b. agarose gel c. sudan black b
agarose gel
39
lipid staining dyes a. oil red o b. crystal violet c. fat red 7b
oil red o fat red 7b sudan black b
40
is an autosomal DOMINANT disorder that caused by DEFICIENT or DEFECTIVE LDL RECEPTOR a. famillial HYPERCHOLEsterolemia b. abetalipoproteinemia c. famillial hyperLIPOPROTEINEMIA
FAMILLIAL HYPERCHOLESTEROLEMIA (TYPE 2A)
41
it involves Exogenous and Endogenous pathway of lipoprotein metabolism a. famillial hypercholesterolemia b. familial hyperlipoproteinemia c. hypobetalipoproteinemia
familial hyperlipoproteinemia
42
laboratory results: equal elevation of CHOLESTEROL AND TAG and presence of B-VLDL a. Abetalipoproteinemia b. familial hyperlipoproteinemia c. hypobetalipoproteinemia
famillial hyperlipoproteinemia
43
abetalipoproteinemia a. tangler's disease b. bassen kornzweig syndrom c. niemann pick disease
Bassen Kornzweig Syndrome
44
Clinical Findings : xanthomas and PREMATURE VASCILAR DISEASE (CHD AND PERIPHERAL ARTERY DISEASE) a. famillial hypercholesterolemia b. familial hyperlipoproteinemia c. hypobetalipoproteinemia
b. familial hyperlipoproteinemia
45
Clinical Findings : xantholesma and PLANAR xanthomas a. famillial hypercholesterolemia b. familial hyperlipoproteinemia c. hypobetalipoproteinemia
a. famillial hypercholesterolemia
46
is autosomal RECESSIVE disorder , DEFECTIVE APO B SYNTHESIS a. famillial hypercholesterolemia b. familial hyperlipoproteinemia c. Abetalipoproteinemia
abetalipoproteinemia Hypobetalipoproteinemia -- due to apo b deficiency resulting from POINT MUTATION IN APO-B
47
characterized by : Cereberal ataxia, Acanthocytosis, Fat malabsorption a. abetalipoproteinemia b. familial hyperlipoproteinemia c. hypobetalipoproteinemia
abetalipoproteinemia
48
inherited disorder of lipid metabolism in which there are acummulation of spingomyelin in the bone marrow, spleen and lymph nodes a. niemann pick disease b. tangler's disease c. tay sachs
niemann pick disease
49
complete absence of HDL due to mutation in the ABCA1 gene on chromosome 9 a. niemann pick disease b. tangler's disease c. tay sachs
tangler's disease tanglers is a rare autosomal recessive disorder
50
Clinical Findings: orange or yellow dscoloration of the tonsils and pharynx a. niemann pick disease b. tangler's disease c. tay sachs
tangler's disease
51
it is a rare autosomal recessive disorder that is presents in childhood with abdominal pain and pancreatitis a tangler's disease b. tay sachs c. LPL deficiency
lpl deficiency
52
Clinical Findings : Corneal Opacities, Normochromic anemia, and renal failure in young adults a. niemann pick disease b. tangler's disease c. tay sachs d. lcat deficiency
lcat deficiency
53
milder form of Lecithin Cholesterol acyl transferase disease a. fish eye disease b. tay sach disease c. andersen disease
fish eye disease
54
it is inherited neurodegenerative disorder of lipid metabolism a. niemann pick disease b. tangler's disease c. tay sachs
tay sachs disease
55
deficiency of enzyme hexominidase a a. niemann pick disease b. tangler's disease c. tay sachs
tay sachs disease
56
Clinical Findings: Fat malabsorption and low levels of plasma lipids a. sitosterolemia b. chylomicron retention disease c, LCAT deficiency
chylomicron retention disease ( Anderson's disease)
57
this is distinct of abetalipoproteinemia, as only apoB-48 appears to be affected a. sitosterolemia b. chylomicron retention disease c, LCAT deficiency
chylomicron retention disease ( Anderon's disease) CRD and Abetalpp they are both deficiency of fat soluble vitamins. BUT crd is Vit. E to be particular while Abetalpp is Vit AEK
58
is a recessive disorder wherein PLANT STEROLS are absorbed and accumulate in plasma and peripheral tissue a. sitosterolemia b. chylomicron retention disease c, LCAT deficiency
sitosterolemia
59
mutation of ABCG8 OR ABCG5 both located on chromosome 2p21 a. sitosterolemia b. tangler's disease c, Lcat deficiency
sitosterolemia tangler's disease -----> mutation of ABCA1 gene on chromosome 9
60
Laboratory Results; high HDL-C during Childhood a. sitosterolemia b. chylomicron retention disease c, LPL defucuency
sitosterolemia
61
unsaturated steroid alcohol a. spingosine b. phospholipid c. cholesterol
cholesterol Spingosine - is an amino alcohol where spingomyelin derived form
62
cholesterol its transport and excretion is promoted by? a. androgens b. estrogen c. mineralocorticoids
estrogen
63
It evaluated the risk for ATHEROSCLEROSIS, MYOCARDIAL AND CORONARY ARTERIAL OCCLUSIONS a. phospholipids b. cholesterol c. fatty acids
cholesterol
64
it is used to test the effectiveness of lifestyle changes and stress management a. phospholipids b. cholesterol c. triglycerides
cholesterol
65
Polar non esterified alcohol a. cholesterol ester b. free cholesterol
free cholesterol
66
what is the end color for Lieberman Burchardt reaction a. red end color b. green end color c. blue green end color
green end color Liebermann Burchard reaction Cholestadienyl Monosulfonic Acid (green end product)
67
what is the End product for Salkowski Reaction a. Cholestadienyl MONOsulfonic Acid b. Cholestadienyl DIsulfonic Acid
Salkowski Reaction | end product : Cholestadienyl DIsulfonic Acid ( red end color)
68
color developer mixture (liebermann Burchardt Reagent) 1. 2. 3.
a. Glacial acetic Acid b. acetic anhydride c. concentrated h2so4
69
main storage lipid of man a. cholesterol b. phospholipid c. tag
tag
70
fasting requirement for TAG a. 8-10 hrs b. 12-18hrs c. 12-14hrs
12-14 hrs

Clinical Chemistry (4 decks)

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