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Clinical Chemistry > lipid and lipoproteins > Flashcards

lipid and lipoproteins Flashcards

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1
Q

it helps to keep lipids in solution (solubililty) during circulation through the bloodstream

a. apolipoproteins
b. chylomicrons
c. lipoprotein

A

apolipoproteins

lipoprotein—- is a large macromolecule complexes of lipids

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2
Q

amphiphatic helix

a. structural motif of apolipoproteins
b. vit. e depends on amphi helix fior absorption
c. ability of proteins to bind to lipids

A

a&c

structural motif of apolipoprotein- amphiphatic helix—-> ability of proteins to bind to lipids

vit. e depends of CHYLOMICRONS for absorption

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3
Q

Beta lipoprotein

a. HDL
b. VLDL
c. LDL

A

LDL

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4
Q

pre beta lipoprotein

a. HDL
b. VLDL
c. LDL

A

vldl

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5
Q

alpha lipoprotein

a. hdl
b. vldl
c. ldl

A

hdl

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6
Q

LARGEST but LEAST DENSE

a. Hdl
b. CM
c. IDL

A

chylomicrons

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7
Q

smallest but most dense

a. hdl
b. ldl
c, cm

A

hdl

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8
Q

reverse cholesterol transport

a. hdl
b. vldl
c. ldl

A

hdl

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9
Q

nascent disk shaped particles

a. hdl
b. vldl
c. ldl

A

hdl

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10
Q

transport endogenous tag from the liver to the muscle, fat depots and tissues

a. cm
b. vldl
c. hdl
d. ldl

A

vldl

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11
Q

transport exogenous

a. cm
b. vldl
c. hdl
d. ldl

A

cm

ExCHY

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12
Q

HDL that transports effectively the lipids to the liver and more cardioactive

a. hdl1
b. hdl2
c. hdl3

A

HDL2

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13
Q

major end product from the catabolism of VLDL

a. hdl
b. ldl
c, cm

A

ldl

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14
Q

primary marker for CHD risk

a. cm
b. ldl
c. hdl
d. vldl

A

ldl

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15
Q

research method for LDL

a. abell kendal
b. ultracentrifugation
c, beta quantitation

A

beta quantitation

HDL cdc reference method:

ultacentrifugation
precipitation with heparin mncl
abell kendall

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16
Q

what are the MINOR LIPOPROTEINS

A
  1. INTERMEDIATED LIPOPROTEIN

2. LIPOPROTEIN A

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17
Q

it maintains the equilibrium of cholesterol in peripheral cells

a. CM
b. HDL
c. VLDL

A

HDL

it maintains the equilibrium of cholesterol in peripheral cells BY REVERSE CHOLESTEROL TRANSPORT PATHWAY

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18
Q

SYNTHESIZED by the Liver

a. hdl
b. vldl
c. ldl

A

LDL

LDL —> SYNTHESIZED in the liver
VLDL —> S E C R E T E D in the liver
{Vsec)
HDL —> P R O D U C E D in the Liver and Intestine {produH)

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19
Q

the MAJOR SOURCE OF CHOLESTEROL for tissue

a. HDL
b. LDL
c. LpA

A

LDL

it constitutes 50% ot the TOTAL LPP IN PLASMA

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20
Q

PRODUCT of VLDL catabolism

a. LDL
b. IDL
c. Lpp (a)

A

IDL

LDL —> END PRODUCT of VLDL catabolism

IDL —> PRODUCT of VLDL catabolism

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21
Q

VLDL REMNANT

a. LDL
b. IDL
c. Lpp (a)

A

IDL

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22
Q

CONVERTED TO LDL

a. VLDL
b. IDL
c. Lpp (a)

A

IDL

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23
Q

SUBCLASS OF LDL

a. VLDL
b. IDL
c. Lpp (a)

A

IDL

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24
Q

Defective clearance of Intermediate density lpp

a. type 1 hyperlipoproteinemia
b. type 3 hyperlipoproteinemia
c. tay sach’s disease

A

type 3 hyperlipoproteinemia

probably due to apo E-III

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25
Q

SINKING lipoprotein

a. HDL
b. IDL
c. Lpp (a)

A

lpp (A)

A boat is SINKING

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26
Q

increased may indicate PREMATURE CORONARY HEART DISEASE

A. LDL
B. IDL
C. LPP (a)

A

LPP (a)

INCREASED LIPOPROTEIN A MAY INDICATE PREMATURE CHD AND STROKE

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27
Q

INDPENDENT RISK FACTOR OF ATHEROSCLEROSIS

a. LDL
b. IDL
c. Lpp (a)

A

LPP (A)

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28
Q

SENSITIVITE and SPECIFIC indicator of CHOLESTASIS

a. IDL
B. LPP a
c. LPP x

A

LPP X

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29
Q

it is an abnormal lpp that can be found in OBSTRUCTIVE JAUNDICE AND LCAT DEFICIENCY

a. IDL
B. BETA VLDL
c. LPP X

A

LPP X

30
Q

VLDL RICH IN CHOLESTEROL

a. LDL
B. BETA VLDL
c. LPP x

A

BETA VLDL

31
Q

it can be found in type 3 hyperlpp or dybetalpp

a. IDL
B. beta vldl
c. LPP x

A

beta vldl

IDL—-> Defective clearance of Intermediate density lpp- type 3 hyperlpp- probably due to apo e - III

b-VLDL——> it can be found in type 3 hyperlpp or dybetalpp

32
Q

this sample occurs in non fasting samples of patient with HYPERLIPIDEMIA OR PATIENT RECEIVING TPN THERAPY

a. hemolysed samples
b. lipemic samples

A

lipemic sample

33
Q

if NON FASTING SAMPLE is to be test, what test can be test?

a. TAG and LDL-C
b. TC and HDL-C
c. TAG and TC

A

TOTAL CHOLESTEROL (TC) and HDL-C

TAG and LDL-C are being measured, FASTING BECOMES A REQUIREMENT

34
Q

REFERENCE METHOD for quantitation of lpp

a. ultracentrifugation
b. electophoresis
c. chemical precipitation

A

ultracentrifugation

35
Q

electtropheresis is expressed by whta unit?

A

svedverg

36
Q

reagent used in electrophoresis

a. sodium potassium solution
b. potassium bromide solution
c. potassium manganese solution

A

potassium bromide solution with density of 1.063

37
Q

electrophoretic pattern

A

HDL, VLDL, LDL, CHYLOMICRON

HDL - A lpha
VLDL- PRE B
LDL- B ETA

38
Q

PREFERRED SUPPORTING MEDIUM FOR ELECTROPHORESIS

a. edta
b. agarose gel
c. sudan black b

A

agarose gel

39
Q

lipid staining dyes

a. oil red o
b. crystal violet
c. fat red 7b

A

oil red o
fat red 7b
sudan black b

40
Q

is an autosomal DOMINANT disorder that caused by DEFICIENT or DEFECTIVE LDL RECEPTOR

a. famillial HYPERCHOLEsterolemia
b. abetalipoproteinemia
c. famillial hyperLIPOPROTEINEMIA

A

FAMILLIAL HYPERCHOLESTEROLEMIA (TYPE 2A)

41
Q

it involves Exogenous and Endogenous pathway of lipoprotein metabolism

a. famillial hypercholesterolemia
b. familial hyperlipoproteinemia
c. hypobetalipoproteinemia

A

familial hyperlipoproteinemia

42
Q

laboratory results:
equal elevation of CHOLESTEROL AND TAG and presence of B-VLDL

a. Abetalipoproteinemia
b. familial hyperlipoproteinemia
c. hypobetalipoproteinemia

A

famillial hyperlipoproteinemia

43
Q

abetalipoproteinemia

a. tangler’s disease
b. bassen kornzweig syndrom
c. niemann pick disease

A

Bassen Kornzweig Syndrome

44
Q

Clinical Findings : xanthomas and PREMATURE VASCILAR DISEASE (CHD AND PERIPHERAL ARTERY DISEASE)

a. famillial hypercholesterolemia
b. familial hyperlipoproteinemia
c. hypobetalipoproteinemia

A

b. familial hyperlipoproteinemia

45
Q

Clinical Findings : xantholesma and PLANAR xanthomas

a. famillial hypercholesterolemia
b. familial hyperlipoproteinemia
c. hypobetalipoproteinemia

A

a. famillial hypercholesterolemia

46
Q

is autosomal RECESSIVE disorder , DEFECTIVE APO B SYNTHESIS

a. famillial hypercholesterolemia
b. familial hyperlipoproteinemia
c. Abetalipoproteinemia

A

abetalipoproteinemia

Hypobetalipoproteinemia – due to apo b deficiency resulting from POINT MUTATION IN APO-B

47
Q

characterized by : Cereberal ataxia, Acanthocytosis, Fat malabsorption

a. abetalipoproteinemia
b. familial hyperlipoproteinemia
c. hypobetalipoproteinemia

A

abetalipoproteinemia

48
Q

inherited disorder of lipid metabolism in which there are acummulation of spingomyelin in the bone marrow, spleen and lymph nodes

a. niemann pick disease
b. tangler’s disease
c. tay sachs

A

niemann pick disease

49
Q

complete absence of HDL due to mutation in the ABCA1 gene on chromosome 9

a. niemann pick disease
b. tangler’s disease
c. tay sachs

A

tangler’s disease

tanglers is a rare autosomal recessive disorder

50
Q

Clinical Findings: orange or yellow dscoloration of the tonsils and pharynx

a. niemann pick disease
b. tangler’s disease
c. tay sachs

A

tangler’s disease

51
Q

it is a rare autosomal recessive disorder that is presents in childhood with abdominal pain and pancreatitis

a tangler’s disease

b. tay sachs
c. LPL deficiency

A

lpl deficiency

52
Q

Clinical Findings : Corneal Opacities, Normochromic anemia, and renal failure in young adults

a. niemann pick disease
b. tangler’s disease
c. tay sachs
d. lcat deficiency

A

lcat deficiency

53
Q

milder form of Lecithin Cholesterol acyl transferase disease

a. fish eye disease
b. tay sach disease
c. andersen disease

A

fish eye disease

54
Q

it is inherited neurodegenerative disorder of lipid metabolism

a. niemann pick disease
b. tangler’s disease
c. tay sachs

A

tay sachs disease

55
Q

deficiency of enzyme hexominidase a

a. niemann pick disease
b. tangler’s disease
c. tay sachs

A

tay sachs disease

56
Q

Clinical Findings: Fat malabsorption and low levels of plasma lipids

a. sitosterolemia
b. chylomicron retention disease
c, LCAT deficiency

A

chylomicron retention disease ( Anderson’s disease)

57
Q

this is distinct of abetalipoproteinemia, as only apoB-48 appears to be affected

a. sitosterolemia
b. chylomicron retention disease
c, LCAT deficiency

A

chylomicron retention disease ( Anderon’s disease)

CRD and Abetalpp they are both deficiency of fat soluble vitamins. BUT crd is Vit. E to be particular while Abetalpp is Vit AEK

58
Q

is a recessive disorder wherein PLANT STEROLS are absorbed and accumulate in plasma and peripheral tissue

a. sitosterolemia
b. chylomicron retention disease
c, LCAT deficiency

A

sitosterolemia

59
Q

mutation of ABCG8 OR ABCG5 both located on chromosome 2p21

a. sitosterolemia
b. tangler’s disease
c, Lcat deficiency

A

sitosterolemia

tangler’s disease —–> mutation of ABCA1 gene on chromosome 9

60
Q

Laboratory Results; high HDL-C during Childhood

a. sitosterolemia
b. chylomicron retention disease
c, LPL defucuency

A

sitosterolemia

61
Q

unsaturated steroid alcohol

a. spingosine
b. phospholipid
c. cholesterol

A

cholesterol

Spingosine - is an amino alcohol where spingomyelin derived form

62
Q

cholesterol its transport and excretion is promoted by?

a. androgens
b. estrogen
c. mineralocorticoids

A

estrogen

63
Q

It evaluated the risk for ATHEROSCLEROSIS, MYOCARDIAL AND CORONARY ARTERIAL OCCLUSIONS

a. phospholipids
b. cholesterol
c. fatty acids

A

cholesterol

64
Q

it is used to test the effectiveness of lifestyle changes and stress management

a. phospholipids
b. cholesterol
c. triglycerides

A

cholesterol

65
Q

Polar non esterified alcohol

a. cholesterol ester
b. free cholesterol

A

free cholesterol

66
Q

what is the end color for Lieberman Burchardt reaction

a. red end color
b. green end color
c. blue green end color

A

green end color

Liebermann Burchard reaction
Cholestadienyl Monosulfonic Acid (green end product)

67
Q

what is the End product for Salkowski Reaction

a. Cholestadienyl MONOsulfonic Acid
b. Cholestadienyl DIsulfonic Acid

A

Salkowski Reaction

end product : Cholestadienyl DIsulfonic Acid ( red end color)

68
Q

color developer mixture (liebermann Burchardt Reagent)

1.
2.
3.

A

a. Glacial acetic Acid
b. acetic anhydride
c. concentrated h2so4

69
Q

main storage lipid of man

a. cholesterol
b. phospholipid
c. tag

A

tag

70
Q

fasting requirement for TAG

a. 8-10 hrs
b. 12-18hrs
c. 12-14hrs

A

12-14 hrs

Clinical Chemistry (4 decks)

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