Liver Function 2 Flashcards
Where does the liver get its blood supply from?
The hepatic portal vein and hepatic arteries
Where does the hepatic portal vein carry venous blood drained from?
Spleen, GI tract and its associated organs
What type of liver cells are parenchymal?
Hepatocytes - 80% liver volume
What live cells are non parenchymal?
Endothelial cells
Kupffer cells
Sinusoidal
What do bipotential stem cells form?
Ovalocytes form hepatocytes and cholangiocytes
What are the functions of the liver?
Synthesis
Breakdown
Storage
Immune system
What does the liver synthesise?
Amino acids
What does the liver metabolise?
Carbohydrates, proteins and lipids
In the first trimester foetus what is the liver the main site of?
Red blood cell production
What happens to bile synthesised by the liver?
Some bile drains directly into the duodenum, and some is stored in the gallbladder
What is the role of IGF-1 that is produced by the liver?
Important role in childhood growth and continues to have anabolic effects in adults
The liver is a major site of thrombopoetin production. What is the role of thrombopoietin?
Thrombopoietin is a glycoprotein hormone that regulates the production of platelets by the bone marrow
What is the liver involved in the breakdown of?
Breakdown of insulin and other hormones
Glucoronidates bilirubin, facilitating its excretion into bile
Toxic substances
Drug metabolism - sometimes results in toxication. Toxins are conjugated to avail excretion n bile or urine
Converts ammonia to urea (urea cycle)
How does the liver have immunological effects?
The reticuloendothelial system of the liver contains many immunologically active cells, acting as a sieve for antigens carried to it via the portal system
What is the role of albumin in blood serum?
It is the major osmolar component of blood serum