Liver failure Flashcards

1
Q

Causes

A

Paracetamol overdose

Alcohol

Viral hepatitis (usually A or B)

Acute fatty liver of pregnancy

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2
Q

Features

A

Jaundice

Coagulopathy (raised PT time)

Hypoalbuminaemia

Hepatic encephalopathy

Renal failure

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3
Q

Paracetamol overdose management

A

Within 1 hour may benefit from activated charcoal

Acetylcysteine if
- high plasma paracetamol concentration
- staggered overdose

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4
Q

Paracetamol overdose liver transplant criteria

A

Arterial pH <7.3 24 hours after ingestion or all of

  • PT time >100 seconds
  • creatinine >300umol/l
  • grade III or IV encephalopthy
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