Liver Disease In Pregnancy Flashcards
1
Q
Risk factors for hyperemesis gravidarum
A
Hyperthyroidism Psychiatric illness Molar pregnancy Multiple gestation (twin) Preexisting diabetes
2
Q
ABG due to vomiting
A
Hypokalemic and hypochloremic metabolic alkalosis
3
Q
Lab abnormalities hyperemesis gravidarum
A
ALT and AST increase Increase Hb Ketosis Hypokalemia hypocloremia metabolic alkalosis Increased BUN
4
Q
Treatment hyperemesis gra
A
Fluids Antihistamine: doxylamine and pyridoxine (B6) Dopamine antagonist Serotonin antagonist Thiamin supplement
5
Q
Ethology of ICP
A
Genetic (mutation in ABCB4)
Hormones: estrogen and progesterone
Environmental
6
Q
Clinical features of ICP
A
Pruritus: palms, soles of feet, worse at night
Jaundice
Abdominal pain
Encephalopathy
Lab: increased BA
7
Q
Hyperemesis gravidarum
Onset
Peak
Resolution
A
Onset: 5-6 week
Peak: 9th
Usually resolve by week 20
8
Q
Treatment of ICP
A
UDCA: decrease BA
Cholestyramine
Hydroxyzine
9
Q
Clinical feacture of acute fatty liver of pregnancy
A
Presents in 3rd trimester N/V Upper abdominal pain Pruritus Jaundice Confusion Preeclampsia 50 % Anorexia and malaise
10
Q
Diagnosis of AFLP
A
Liver biopsy or CT
11
Q
Lab values AFLP
A
Increased AST> ALT
Increased PTT
Hypoglycaemia
