Liver Flashcards
Ductus venosus becomes
Ligamentum venosum
Umbilical vein becomes
Ligamentum teres/ round ligament after birth
Opens back in portal htn. Re canalized umbilical vein.
Largest organ in the body
Liver
Liver is an intraperitoneal organ except the
Bare area. (Area not covered by peritoneum) adj to GB fossa, porta hepatis, and area surrounding IVC.
Liver
Weighs 1500grams Trvs 20-22.5 cm AP 20-12.5 L 15-20 cm Convex at diaphragm concave at visceral surface
Glisson’s capsule aka visceral peritoneum
Fibroelastic connective tissue covering the liver. Has vessels, lymphatics, & nerves.
Ligaments
Coronary: where parietal becomes visceral layer. Gives rise to rt & lt triangular ligament
Falciform ligament: divides r & l lobes
Round ligament/Ligamentum Teres
Rt triangular
Lt triangular / lateral ligament
Gastrohepatic
Hepatoduodenal
Ligamentum venosum/hepatogastric lig (post to liver): separates lt lobe & caudate
Anatomical division
- ) Right lobe (includes caudate and quadrate)
- ) Left love
Further divided…4 lobes
- ) right
- ) left
- ) caudate
- ) quadrate
Segmental division
- ) right lobe
- ) left lobe (including quadrate)
- ) caudate
Couinaud Segments
Used for liver resection
- ) caudate lobe
- ) lateral segment lt lobe sup
- ) lateral segment lt lobe inf
- ) quadrate/ medial segment lt lobe sup and inf
- ) ant segment rt lobe inf
- ) posterior segment rt lobe inf
- ) post segment rt lobe sup
- ) ant segment rt lobe sup
Liver blood supply and drainage
Hepatic artery: O2 rich
Portal vein: nutrient rich. Most of liver is supplied by PV
Hepatic veins into ivc drains
Liver function carried out by
Hepatocytes, biliary epithelial cells, kupffer cells (phagocytes)
Liver functions
Digestion, carb metabolism, storage, protein metabolism, detoxification
LFT’s
Alt, AST, bilirubin, alk phos, LDH, alp, ggtp/ggt inc with alcohol abuse, pt, dec albumin, afp inc cancer.
Reidel’s lobe
Tongue like projection of rt lobe
Transplant Doppler
Normal: RI < 0.8, acceleration time < 0.08, low resistant artery wave.
PRF, 45-60*, depth, sm color box, gain, wall filter, power Doppler on slow flow.
Most common liver transplant complication
Ischemic reprofusion injury
Rejection confirmed with biopsy
2nd most common = hepatic artery stenosis
Stenosis
Distal tardus parvus wave, vel > 200 cm/s, color aliasing at stenosis
Hepatic veins
Right middle left
Ligamentum venosum divides
Medial segment Left lobe and caudate lobe.
Remnant of ductus venosus
Ligamentum teres divides
Medial and lateral segments of the left lobe.
Lab decreases with chronic liver disease
Serum albumin
What liver segment is between the left hepatic vein and the middle hepatic vein?
MSLL
Reticuloendothelial tissue activity
Digestion of hemoglobin released from ruptured red blood cells.
Phagocytic function of the liver is carried out by
Kupffer cells
What are the boundaries of the quadrate lobe?
GB fossa, lig teres
Milan criteria for patient with HCC
No lesion > 5cm,
Reye’s syndrome
Associates with pediatric use of aspirin
Von Gierkes Type I
MC Glycogen storage disease
Wilson’s disease
Copper disease. Must avoid organ foods such as liver kidney heart nuts and dried beans.
Brown rings around eyes called Kayser-Fleischer Ring
Schistosomiasis
Turtle back liver. From snails in water penetrate skin. Leads to portal htn & pipe stem cirrhosis
Portal vein occlusion by the larvae leads to portal htn, splenomegaly, ascites, and varices
Amoebiasis
Protozoa amoeba can lead to liver dysfunction and abscess, primarily affects colon.
Candidiasis
Fungus balls, immunosuppressed
Echinococcus / Hydatid disease
Honey comb appearance/water lily sign/ lily pad, tapeworm, dog poop in sheep heard and humans eat infected sheep. Egg travels through portal to liver.
Echinococcal cyst/hydatid cyst/daughter cyst
Large cyst with small daughter cysts. Hydatid sand internal echoes seen.
Changes & can turn into collapsed calcified mass.
Pneumocystitis
Pneumocystis Carinii
Affects lungs mostly, immunosuppressed patients. Numerous echogenic foci
MC organism to affect AIDs patients 80%. May manifest as pneumonia.
Hepatitis
Acute hepatitis: starry sky liver, hypo liver, enlarged, portal veins inc echoes in the bands known as periportal cuffing.
Chronic: hyperechoic small liver, dec echo of PV
A-daycare workers, oral/fecal/water, wash hands after changing diapers, Vaccine Hep A available, self limiting
B-blood/body fluids/unprotected sex/needles. Vaccine Hep B, healthcare workers at risk
C-blood
D-from Hep B, hep B vaccine.
E-food/water
G-? True hepatitis
Gaucher’s disease
Error of lipid metabolism, Type I MC, glucoscerobrocyde lipid accumulates in organs bc of enzyme deficiency
Enzyme replacement therapy
Bruising, low platelets, anemic, tired.
Hepatosplenomegaly
Hemochromatosis
Iron overload, gets in organs
Joint pain.
Phlebotomy removed excess iron take out a pint 1-2 weeks for months and maintenance therapy blood given every 2-4 months for life.