Lithium Flashcards
What is lithium?
mood stabiliser, available in many salts like carbonate, citrate and orotate
what class of drugs does lithium belong to?
antipsychotic agents
What are other drugs in the same class as lithium?
Risperidone Clozapine Quetiapine Droperidol Sodium valproate Haloperidol decanoate Chlorpromazine
What is lithium indicated for?
treatment and prophylaxis of mania, hypomania and depression in bipolar disorder
- prophylaxis and treatment of recurrent unipolar depression
- concomitant therapy with antidepressant meds
What is the relevance of lithium in thyroid disease?
Lithium is concentrated by the thyroid and inhibits thyroidal iodine uptake, iodotyrosine coupling
-alters thyroglobulin structure and inhibits thryoird hormone secretion resulting in hypothyroidism and goitre.
What is the mechanism of lithium?
interacts with transport of monovalent or divalent cations in neurons
stabilisers glutamate by changing the inward and outward currents of glutatmate receptors
non competitively inhbits inositolmonophosphatase
