Listeria & Erysipelothrix Flashcards

1
Q

What kind of bacteria are Listeria?

A

Small, Gram +, coccobacilli-rods

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2
Q

What are the key points about Listeria?

A

Ubiquitous in the environment

Carried in a wide variety of animals as asymptomatic enteric carriers

Poor silage and food items are common source of outbreaks

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3
Q

What is the clinical significance of Listeria monocytogenes?

A

Winter/spring disease of feedlot our housed ruminants

Outbreaks due to poor quality silage

Economically important disease with seasonal occurrence (winer months)

Ingestion/inhalation or enter via minute wounds in buccal mucosa

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4
Q

Where does L. monocytogenes localize?

A

Localize in brain stem, intestinal wall, and placenta

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5
Q

What does L. monocytogenes cause?

A

Septicemia, abortion, and encephalitis

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6
Q

What are the two forms of Listeriosis?

A
  1. Visceral

2. Neural (predominantly in ruminants)

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7
Q

What is the pathogenesis of L. monocytogenes?

A

Invasive / Enters blood stream

Facultative intracellular bacteria: persist in macrophages

Intracellular growth

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8
Q

What are the virulence factors of L. monocytogenes?

A

Internalin

Listeriolysin (hemolysin)

Act A

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9
Q

What is the most common disease presentation in ruminants for L. monocytogenes?

A

Encephalitis: Have an affinity for brainstem

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10
Q

What is the common disease presentation in monogastric and newborn animals for L. monocytogenes?

A

Septicemia

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11
Q

The abortion the L. monocytogenes causes can result in what?

A

Focal hepatic necrosis

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12
Q

What are the neurologic symptoms in ruminants for L. monocytogenes?

A

Dullness, turning or twisting, walking in circles

Unilateral trigeminal and facial paralysis

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13
Q

What are the lesions in ruminants for L. monocytogenes?

A

Prominent lesions in brain stem

Microabscesses and glial nodules

Meningitis

Acute vascular fibroid necrosis

Neuronal necrosis, neuritis and perineuritis of cranial nerves

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14
Q

In cases of septicemia, how would you DX L. monocytogenes?

A

Culture liver and spleen

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15
Q

Would you treat CNS disease in ruminants for L. monocytogenes?

A

Not usually

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16
Q

What are the drugs that L. monocytogenes is susceptible to?

A

Penecillin, ceftiofur, tetracycline, erythromycin, and trimethoprim/sulfonamid

17
Q

What is a good drug combo to treatment of L. monocytogenes?

A

Ampicillin and Gentamicin

18
Q

How would you prevent L. monocytogenes in ruminants?

A

Avoid feeding poor quality silage

19
Q

What kind of bacteria are Erysipelothrix?

A

Small, aerobic, Gram + rods

20
Q

What is the most important reservoir for Erysipelothrix rhusiopathiae?

A

Swine

21
Q

What four syndromes are observed in swine with E. rhusiopathiae?

A
  1. Septicemia
  2. Dermatopathy
  3. Arthritis
  4. Endocarditis
22
Q

How is E. rhusiopathiae primarily transmitted?

A

Orally

23
Q

What is a virulence factor of E. rhusiopathiae?

A

Neuraminidase: leads to vascular damage and hyaline thrombus formation

24
Q

What is the disease that E. rhusiopathiae causes in swine?

A

Skin erysipelas or Diamond skin disease

25
Q

What is the differential diagnosis in swine with E. rhusiopathiae?

A

Dermatitis and neuropathy syndrome

26
Q

How does E. rhusiopathiae affect turkeys and other birds?

A

Acute infection; septicemia

Chronic infection; endocarditis and arthritis

27
Q

How does E. rhusiopathiae affect sheep?

A

Non-suppurative polyarthritis

Outbreaks of post dipping lameness

28
Q

How does E. rhusiopathiae affect humans?

A

Localized cellulitis in fingers

29
Q

What is the occupational hazard for E. rhusiopathiae in humans?

A

Veterinarians, people working with fish, poultry and swine industry

30
Q

What is human erysipelas and what is it caused by?

A

An infectious skin disease caused by Group A beta-hemolytic Streptococci

31
Q

How would you DX E. rhusiopathiae?

A

Culture, PCR

32
Q

How would you TX E. rhusiopathiae?

A

Antimicrobial treatment of acute infections

Intrinsic resistance to vancomycin, ahminoglycosides, sulfonamides

33
Q

How would you control E. rhusiopathiae?

A

Treat and isolate infected animals

Cull chronically affected animals

Good hygiene

Vaccination of pigs and turkeys