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Pathoma - Skin Pathology Ch19 > Lippencott's Ch 24 - Skin > Flashcards

Lippencott's Ch 24 - Skin Flashcards

1
Q

What are scaly, frequently pigmented, elevated papules with scales that are easily rubbed off called?

A

Seborrheic keratoses

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2
Q

What are broad anastomosing cords of mature stratified squamous epithelium associated with small cysts of keratin?

A

Seborrheic keratoses

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3
Q

What is CDKN2A better known as?

A

p16

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4
Q

A mutation in what gene has been found in patients with dysplastic nevus/melanoma?

A

Cyclin Dependent Kinase 2A (CDKN2A)

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5
Q

What kind of gene is CDKN2A?

A

Tumor Suppressor Gene

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6
Q

What can actinic keratoses lead to?

A

Squamous Cell Carcinoma

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7
Q

What is the following describing: Cytologic atypia and dyskeratosis limited to the basal layers of the stratum spongiosum as well as kyperkeratosis and parakeratosis

A

Actinic Keratosis

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8
Q

What virus plays a role in Kaposi Sarcoma?

A

HHV-8

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9
Q

What is the following describing: Painful, purple nodules on the dorsal surface of left hand (chronic) with similar lesions found in the liver and lymphnodes

A

Kaposi Sarcoma

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10
Q

What is the genetic component of Ichthyosis vulgaris?

A

Autosomal dominant disorder

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11
Q

Describe the processes that occur in the epidermis of a person with Ichthyosis vulgaris

A

Mild hyperkeratosis and reduced/absent keratohyaline granules in the epidermis

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12
Q

What causes the scaling in Ichthyosis vulgaris?

A

Increased cohesiveness of the stratum corneum

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13
Q

What condition has a thin stratum granulosum?

A

Ichthyosis vulgaris

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14
Q

What is another name for Lentigo maligna melanoma?

A

Hutchinson melanotic freckle

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15
Q

In psoriasis, what cells accumulate in the epidermis? Dermis?

A

Neutrophils; B and T lymphocytes

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16
Q

When are blisters noted in Epidermolysis Bullosa?

A

Frequently after birth

17
Q

Patient presents with separation of the basal layer of the epidermis from the dermis without immunofluorescence. What is the likely Dx?

A

Epidermolysis Bullosa

18
Q

What is the protein targeted in pemphigus vulgaris by autoAbs? Therefore, which layers separate?

A

Desmoglein-3, Stratum spinosum from the stratum basalis

19
Q

What is the most common malignant tumor in persons with pale skin?

A

Basal Cell Carcinoma

20
Q

A patient with papillomatous lesions presents at the clinic. What is the likely Dx?

A

Verruca vulgaris

21
Q

What is Erythema Nodosum frequently associated with?

A

Drugs and microorganisms

22
Q

What are the two basement membrane proteins associated with Bullous Pemphigoid?

A

BPAG1 and BPAG2

23
Q

What skin condition is related to Celiac’s Disease?

A

Dermatitis Herpetiformis

24
Q

What bacteria is associated with acne?

A

Propionibacterium acnes

25
Q

What processes occur in the epidermis of a person with Lichen Planus?

A

hyperkeratosis with little/no parakeratosis, stratum granulosum is thickened

26
Q

What is a big histologic clue to a Lichen Planus Dx?

A

Saw-tooth dermal papillae

27
Q

Where does Lichen planus generally occur?

A

Flexor surfaces of wrists

28
Q

What are Wickham’s Striae?

A

Patches/streaks on oral mucosa present in lichen planus

29
Q

What is Mycosis Fungoides?

A

Variant of cutaneous T-cell lymphoma

30
Q

What is Sezary Syndrome?

A

Systemic dissemination of mycosis fungoides

31
Q

What is another name for cutaneous necrotizing vasculitis?

A

Leukocytoclastic vasculitis

32
Q

Describe pathogenesis of cutaneous necrotizing vasculitis

A

Immune complexes and C5a activate neutrophils which release lysosomal enzymes and obliterate blood vessels

33
Q

What kind of condition is cutaenous necrotizing vasculitis?

A

Hypersensitivity rxn

34
Q

What is a key clinical feature of cutaneous necrotizing vasculitis?

A

Palpable purpura

35
Q

What are Langerhans cells?

A

Antigen presenting cells

36
Q

In what type of skin reaction is Langerhan cell migration to the lymphatics critical?

A

Allergic Contact Dermatitis

37
Q

What cells interact in the sensitization phase of allergic contact dermatitis?

A

Langerhans cells and CD4+ T helper cells

38
Q

What condition is associated with fibrosis and tightening of the skin?

A

Scleroderma

39
Q

What does the mnemonic, “CREST” stand for?

A

calcinosis/anti-centromere, raynaud’s, esophageal dysmotility, sclerodactyly, telangiectasias

Pathoma - Skin Pathology Ch19 (7 decks)

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