Lippencott's Ch 24 - Skin

Question 1

What are scaly, frequently pigmented, elevated papules with scales that are easily rubbed off called?

Answer 1

Seborrheic keratoses

Question 2

What are broad anastomosing cords of mature stratified squamous epithelium associated with small cysts of keratin?

Answer 2

Seborrheic keratoses

Question 3

What is CDKN2A better known as?

Answer 3

p16

Question 4

A mutation in what gene has been found in patients with dysplastic nevus/melanoma?

Answer 4

Cyclin Dependent Kinase 2A (CDKN2A)

Question 5

What kind of gene is CDKN2A?

Answer 5

Tumor Suppressor Gene

Question 6

What can actinic keratoses lead to?

Answer 6

Squamous Cell Carcinoma

Question 7

What is the following describing: Cytologic atypia and dyskeratosis limited to the basal layers of the stratum spongiosum as well as kyperkeratosis and parakeratosis

Answer 7

Actinic Keratosis

Question 8

What virus plays a role in Kaposi Sarcoma?

Answer 8

HHV-8

Question 9

What is the following describing: Painful, purple nodules on the dorsal surface of left hand (chronic) with similar lesions found in the liver and lymphnodes

Answer 9

Kaposi Sarcoma

Question 10

What is the genetic component of Ichthyosis vulgaris?

Answer 10

Autosomal dominant disorder

Question 11

Describe the processes that occur in the epidermis of a person with Ichthyosis vulgaris

Answer 11

Mild hyperkeratosis and reduced/absent keratohyaline granules in the epidermis

Question 12

What causes the scaling in Ichthyosis vulgaris?

Answer 12

Increased cohesiveness of the stratum corneum

Question 13

What condition has a thin stratum granulosum?

Answer 13

Ichthyosis vulgaris

Question 14

What is another name for Lentigo maligna melanoma?

Answer 14

Hutchinson melanotic freckle

Question 15

In psoriasis, what cells accumulate in the epidermis? Dermis?

Answer 15

Neutrophils; B and T lymphocytes

Question 16

When are blisters noted in Epidermolysis Bullosa?

Answer 16

Frequently after birth

Question 17

Patient presents with separation of the basal layer of the epidermis from the dermis without immunofluorescence. What is the likely Dx?

Answer 17

Epidermolysis Bullosa

Question 18

What is the protein targeted in pemphigus vulgaris by autoAbs? Therefore, which layers separate?

Answer 18

Desmoglein-3, Stratum spinosum from the stratum basalis

Question 19

What is the most common malignant tumor in persons with pale skin?

Answer 19

Basal Cell Carcinoma

Question 20

A patient with papillomatous lesions presents at the clinic. What is the likely Dx?

Answer 20

Verruca vulgaris

Question 21

What is Erythema Nodosum frequently associated with?

Answer 21

Drugs and microorganisms

Question 22

What are the two basement membrane proteins associated with Bullous Pemphigoid?

Answer 22

BPAG1 and BPAG2

Question 23

What skin condition is related to Celiac’s Disease?

Answer 23

Dermatitis Herpetiformis

Question 24

What bacteria is associated with acne?

Answer 24

Propionibacterium acnes

Question 25

What processes occur in the epidermis of a person with Lichen Planus?

Answer 25

hyperkeratosis with little/no parakeratosis, stratum granulosum is thickened

Question 26

What is a big histologic clue to a Lichen Planus Dx?

Answer 26

Saw-tooth dermal papillae

Question 27

Where does Lichen planus generally occur?

Answer 27

Flexor surfaces of wrists

Question 28

What are Wickham's Striae?

Answer 28

Patches/streaks on oral mucosa present in lichen planus

Question 29

What is Mycosis Fungoides?

Answer 29

Variant of cutaneous T-cell lymphoma

Question 30

What is Sezary Syndrome?

Answer 30

Systemic dissemination of mycosis fungoides

Question 31

What is another name for cutaneous necrotizing vasculitis?

Answer 31

Leukocytoclastic vasculitis

Question 32

Describe pathogenesis of cutaneous necrotizing vasculitis

Answer 32

Immune complexes and C5a activate neutrophils which release lysosomal enzymes and obliterate blood vessels

Question 33

What kind of condition is cutaenous necrotizing vasculitis?

Answer 33

Hypersensitivity rxn

Question 34

What is a key clinical feature of cutaneous necrotizing vasculitis?

Answer 34

Palpable purpura

Question 35

What are Langerhans cells?

Answer 35

Antigen presenting cells

Question 36

In what type of skin reaction is Langerhan cell migration to the lymphatics critical?

Answer 36

Allergic Contact Dermatitis

Question 37

What cells interact in the sensitization phase of allergic contact dermatitis?

Answer 37

Langerhans cells and CD4+ T helper cells

Question 38

What condition is associated with fibrosis and tightening of the skin?

Answer 38

Scleroderma

Question 39

What does the mnemonic, "CREST" stand for?

Answer 39

calcinosis/anti-centromere, raynaud's, esophageal dysmotility, sclerodactyly, telangiectasias