Epithelial Tumors Flashcards
What is Seborrheic Keratosis? Population?
Benign squamous proliferation; Common tumor in elderly
Seborrheic Keratosis clinical presentation? Histo findings
Raised, discolored plaque on the extremities or face; waxy, “stuck-on” appearance; keratin pseudocysts
What is Leser-Trelat? What underlying condition does it suggest?
Sudden onset of multiple seborrheic keratoses and suggests underlying carcinoma of GI tract
What is Acanthosis Nigricans? Common associated underlying conditions?
Epidermal hyperplasia with darkening of skin often involving axilla or groin; Type II insulin resistance or malignancy (especially gastric carcinoma)
What is basal cell carcinoma?
Malignant proliferation of the basal cells of the epidermis. It is the MOST common cutaneous malignancy.
What are risk factors for basal cell carcinoma?
UVB-induced DNA damage and include prolonged exposure to sunlight, albinism, and xeroderma pigmentosum
What is the clinical presentation of basal cell carcinoma?
Elevated nodule with central ulcerated crater surrounded by dilated vessels “pink, pearl-like papule
What is the classic location of basal cell carcinoma?
Upper lip
Histo findings of basal cell carcinoma?
Nodules of basal cells with peripheral palisading
Tx for BCC? Frequency of metastasis?
Excision, infrequent
What is squamous cell carcinoma?
Malignant proliferation of squamous cells characterized by formation of keratin pearls
Risk factors for SCC?
UVB exposure, prolonged exposure to sunlight, albinism, xeroderma pigmentosum, immunosuppresive Tx, Arsenic exposure, chronic inflammation
SCC clinical presentation?
Ulcerated nodular mass usually on face, classically on lower lip
What is actinic keratosis?
Precursor lesion (dysplasia) of SCC and presents as hyperkeratotic, scaly plaque of face back or neck
What is a Keratoancanthoma? Clinical presentation?
Well differentiated SCC that develops rapidly and regress spontaneously; Presents as cup-shaped tumor filled with keratin debris
