Lipoprotein Physiology again Flashcards
Cholesterol and triglycerides are transported through lymph and blood by a sub-cellular body known as a
lipoprotein
Lipids are transported through the body via lipoproteins along three major routes:
- exogenous pathway
- endogenous pathway
- reverse cholesterol transport
what is the exogenous pathway
gathers lipids from the digestive tract and distributes them throughout the body after a meal
what is the endogenous pathway
the liver builds apoliproteins and secretes them into the bloodstream – also distributes lipids throughout the body
what is the reverse cholesterol transport
scavenges cholesterol from peripheral tissues and returns it to the liver
? are synthesized by the enterocyte
chylomicrons
what is inserted as a structural protein for the chylomicron during the exogenous pathway
ApoB-48
HDL particles transfer ? and ? to the chylomicrons
ApoC-II and ApoA-V
ApoC-II and ApoA-V allow the chylomicron to ?
interact with lipoprotein lipase (LPL)
LPL on the endothelial cells of capillaries do what to the chylomicrons?
cleaves TGs in chylomicrons to FFAs
after TGs are lost, the chylomicron becomes a ?
chylomicron remnant
HDL also transfers ? to the chylomicron so that the chylomicron remnant can be ?
ApoE
cleared by the liver
Chylomicron remnants are cleared by the liver via an ?
ApoE-dependent mechanism (LDL receptor)
what is the function of the exogenous pathway
carry dietary lipids to most cells but especially liver
what is the initial lipoprotein and intermediate lipoprotein of the exogenous pathway
chylomicron and chylomicron remnants
VLDL is synthesized by the ?
liver
VLDL contains what apoproteins
ApoC-II, ApoA-V and ApoB-100
As LPL “drains” triglycerides from VLDL, it becomes ? and then ?
IDL and LDL
IDL that loses TGs and becomes more and more cholesterol-rich becomes ?
LDL