Lipoprotein Metabolism Flashcards
Types of lipoprotein pathology
Primary Hypercholesterolaemia
Primary Hypertrygliceridaemia
Primary mixed hyperlipidaemia
Hypolipidaemia
Primary hypercholesterolaemia types
Familial type II
Polygenic hypercholesterolaemia
Familial hyper-alpha-lipoproteinaemia
Phytosterolaemia
Familial type II hypercholesterolaemia mutations
AD - LDLR, apoB, PCSK9
AR - LDLRAP1
Familial hyper-alpha-lipoproteinaemia mutations
CETP deficiency
Phytosterolaemia
ABC G5 & G8
Primary hypertriglyceridaemia types
Familial type I
Familial type V
Familial type IV
Familial type I mutation
Lipoprotein lipase or apoC II deficiency
Familial type V mutation
apoA V def
Familial type IV mutation
Increased synthesis of TG
Types of Primary mixed hyperlipidaemia
Familial combined hyperlipidaemia
Familial dys-beta-lipoproteinaemia
Familial hepatic lipase deficiency
Types of hypolipidaemia
Abeta-lipoproteinaemia
Hypo-beta-lipoproteinaemia
Tangier disease
Hypo-alpha-lipoproteinaemia
Abeta-lipoproteinaemia mutation
MTP deficiency
Hypo-beta-lipoproteinaemia mutation
Truncated apoB mutation
Tangier Disease mutation
HDL deficiency
Hypo-alpha-lipoproteinaemia mutation
apoA-I mutations
Lipoproteins in order of density (most to least)
- HDL
- IDL
- LDL
- VLDL
- FFA
- Chylomicrons
What does PCSK9 do?
Tx for lipoprotein(a)
Nicotinic acid
Hyperlipidaemia Mx
Conservative
Medical - Statins
Statins MOA
HMG-CoA reductase inhibitor
Reduces intrinsic synthesis of cholesterol in the liver
Statins SEs
Myopathy/rhabdomyolysis
Fatigue
Obesity Mx
Conservative
Bariatric surgery if BMI over 40 or over 35 with comorbidity
Obesity medications MOAs
Orlistat - pancreatic lipase inhibitor
Rimonabant - cannabinoid antagonist
