Lipids Self test

Question 1

2 and 4

Answer 1

2) Chylomicron

4)VLDL

Question 2

6 is an enzyme and 5 contains its substrates:

Who is 8?

Answer 2

Hepatic lipase (6) Hydrolyses TAGs in IDL turning it to LDL.

8 - Lipoprotein Lipase which degrades Chylomicrons and turns VLDL to IDL

Question 3

1 , 2 , 3

Answer 3

1 - Hormone sensitive Lipase

2 - Perilipins

They are both substrates of phosphorylation by PKA

Stimulated by 3:

Glucagon/Epinephrine

Question 4

Answer 4

1 - Cholesterol

2 - Cholesterol Ester

3 - Acyl-CoA Cholesterol Acyl transferase

(ACAT in Cells)

4 - Lecithin Cholesterol Acyl transferase

(LCAT in Plasma)

5 - Lecithin (phosphatadylcholine)

Question 5

Name of the Even Numbers (Blue)

Where does 9 go later ?

Where does 10 go later ?

Answer 5

2 - Acyl-CoA Dehydrogenase

4 - Enoyl Hydratase

6 - Beta-Hydroxyacyl-CoA Dehydrogenase

8 - Thiolase

9 - Acyl-CoA - to Next Beta Oxidation

10 - Acetyl-CoA- to TCA Cycle/Ketonogenesis.

Question 6

Dealing with Odd number fatty acids:

2 , 4 , 6 + Cofactors and Diseases

Answer 6

2 - Propionyl CoA carboxylase, Biotin

4 - Methmalonyl-CoA Racemace

6 - Methmalonyl-CoA Mutase - B12

The last reaction deficiency leads to Secondary Carnitine deficiency - Hypoglycemia and Metabolic Acidosis

Question 7

2 , 4 , 6 , 8 , 11

Answer 7

2 - Thiolase

4 - HMG-CoA Synthase

6 - HMG-CoA Lyase

8 - Acetoacetate Decarboxylase

11 - Beta-Hydroxybutyrate Dehydrogenase

Question 8

Answer 8

1 -PKA (Glucagon)

2 -ACC (Biotin, ATP and Bicarbonate)

3 - Malonyl-CoA

4 -Insulin

5 - Citrate Lyase

6 - Citrate

Question 9

Answer 9

FA Synthase - Domain 2

2 - Ketoacyl Reductase

4 - Hydroxyacyl Dehydratase

6 - Enoyl Reducatase

8 - Ketoacyl Synthase for further Cycles (Malonyl)

7 - Otherwise Thioesterase releases from cycles

Question 10

1 , 2 , 3 , 6

Answer 10

1 - Citrate Lyase

2- Malic Enzyme

3 - Malate Dehydrogenase

6 - CItrate Synthase