Lipids: Lipoprotein Metabolism Flashcards
Describe the generalized structure of a plasma lipoprotein, specifying where neutral lipids, phospholipids, cholesterol, and proteins are located (eg, in the interior or on the surface and why?)
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Given a list of lipoproteins and the % composition of triglycerides, cholesterol, and proteins in each, classify each of the lipoproteins as Chylomicron, VLDL, LDL, or HDL
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Categorize each lipoprotein in terms of density. Explain what dictates this
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Describe where and how each of the lipoproteins is made
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List the primary function of each lipoprotein
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Describe how each of the apolipoproteins helps its associated lipoprotein to achieve its primary function
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Explain how nascent and mature chylomicrons and VLDLs differ from the mature forms
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Compare and contrast the two triglyceride-rich lipoprotein (TRL) particles in terms of size, composition, function, site of production, Define each as far the type of lipids it carries (exogenous vs endogenous?)
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Describe the role of lipoprotein lipase (LPL) in adipose tissue and skeletal muscles in the hydrolysis of triglycerides in TRLs.
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Explain what is meant by “forward” and “reverse” cholesterol transport and discuss the key lipoprotein in each process where it is made and describe its function.
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Describe how LDL brings cholesterol into a cell. Discuss the apoprotein, receptor, and import mechanisms.
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Describe three mechanisms by which cellular (free cholesterol) regulates itself
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Describe HDL’s role in reverse cholesterol transport (from production in the liver, circulatory routes, and uptake in liver). List key proteins (apoproteins, enzymes, carriers, and receptors) involved.
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Discuss 2-3 roles of HDL beyond reverse cholesterol transport.
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Define “Familial Hypercholesterolemia” and discuss its causes and effects.
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