Lipids & Atherosclerosis Flashcards
0
Q
Major risk factors of atherosclerosis
A
Age Male gender Hyperlipidaemia Hypertension Smoking (treble risk of vascular events- stops- reduced by 1/3) Diabetes Mellitis Family History of premature CVD Obesity, sedetary lifestyle
1
Q
What is atherosclerosis
A
Disease of medium- large arteries Chronic inflammatory response Accumulation of lipid laden macrophages Common Affects coronary, peripheral, renal arteries etc
2
Q
What causes a clinical event in Atherosclerosis?
A
Plaque thrombosis
3
Q
What lipids are in the plasma?
A
Cholesterol
Phospholipid
TAG
4
Q
Lipid lowering drugs
A
Statins Fibrates Bile acid sequestrants Cholesterol uptake inhibitors Fish oil derivatives
5
Q
Types of statins
A
Prava- Fluva- Simva- Atorvo- Rosuva-
Reduce LDL
Inhibit HMG CoA Reductase
6
Q
Statin adverse effects
A
Myositis (CK >5 uln) Liver disturbance (AST >3 uln)
Generally well tolerated
