Ca Channel Blockers & Diuretics Flashcards

0
Q

What do CCBs cause?

A

Vascular SM cell relaxation

Depressed conduction in AV node

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1
Q

Ca blockers are used to manage…

A

Hypertension
Angina
Cardiac arythmias

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2
Q

3 classes of CCB

A

Dihydropyridines (amlodopine)

Phenylalklamines (verapamil)

Benzothiapenes (diltiazem)

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3
Q

Nifedipine is used to treat…

A

Hypertension & angina

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4
Q

Verapamil is used to treat…

A

Cardiac arythmias & angina

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5
Q

Half life of oral 10mg dose of Nifedipine

A

2 hours

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6
Q

Diltiazem treats….

A

Angina
Hypertension
Arythmias

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7
Q

Nifedipine / amlodopine ADRs & contra’

A

ADRs: reflex tachycardia, ankle swelling

Contra’: Cardiogenic shock, aortic stenosis

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8
Q

Diltiazem ADRs & contra’

A

ADRs: AV block

Contra’: Cardiogenic shock, aortic stenosis

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9
Q

Verapamil ADRs & contra’

A

ADRs: AV block

Contra’: Cardiac failure. BETA BLOCKERS!!

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10
Q

Name an osmotic diuretic

A

Mannitol

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11
Q

Name a loop-acting diuretic

A

Furosemide

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12
Q

Osmolarity

A

Moles of ions per litre of solution (Osm/L)

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13
Q

Osmolality

A

Moles of ions per kg of solvent (Osm/kg)

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14
Q

What’s the most potent diuretic?

A

Furosemide

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15
Q

What weak diuretic spares potassium & acts in the collecting ducts?

A

Spironolactone

Blocks aldosterone receptors
No hypokalaemia :)
Gynacomastia :(