Ca Channel Blockers & Diuretics Flashcards
What do CCBs cause?
Vascular SM cell relaxation
Depressed conduction in AV node
Ca blockers are used to manage…
Hypertension
Angina
Cardiac arythmias
3 classes of CCB
Dihydropyridines (amlodopine)
Phenylalklamines (verapamil)
Benzothiapenes (diltiazem)
Nifedipine is used to treat…
Hypertension & angina
Verapamil is used to treat…
Cardiac arythmias & angina
Half life of oral 10mg dose of Nifedipine
2 hours
Diltiazem treats….
Angina
Hypertension
Arythmias
Nifedipine / amlodopine ADRs & contra’
ADRs: reflex tachycardia, ankle swelling
Contra’: Cardiogenic shock, aortic stenosis
Diltiazem ADRs & contra’
ADRs: AV block
Contra’: Cardiogenic shock, aortic stenosis
Verapamil ADRs & contra’
ADRs: AV block
Contra’: Cardiac failure. BETA BLOCKERS!!
Name an osmotic diuretic
Mannitol
Name a loop-acting diuretic
Furosemide
Osmolarity
Moles of ions per litre of solution (Osm/L)
Osmolality
Moles of ions per kg of solvent (Osm/kg)
What’s the most potent diuretic?
Furosemide