Lipids Flashcards
Fatty acids are stored as
TRIACYLGLYCEROL
Enzyme in DHAP (glycolysis)
Glycerol-3 phosphate dehydrogenase
In liver & tissue
Enzyme in phosphorylation of free glycerol
Glycerol kinase
Liver ONLY
Enzyme?
Triacylglycerol -> glycerol + 3 FAs
Hormone-sensitive lipase
Mobilization of stored fats is activated by
Glucagon and epinephrine
Phosphorylation
Mobilization of stored fats is inhibited by
Insulin
Dephosphorylation
Beta oxidation occurs in
Muscle and liver
FA activation - cytosol
B oxidation - mitochondria
Rate limiting step in beta oxidation
Translocation of fatty acyl coA
Enzyme in translocation of fatty acyl coA from cytosol to mitochondria
Carnitine-palmitoyl transferase
ATP yield of palmitate
106
Nadh 17.5 Fadh 10.5 Acetyl coA 80 Activation -2 106 atp
ATP of 1 NADH
2,5
ATP of FADH
1.5
Propionyl CoA requires
Biotin
Methymalonyl CoA mutase requires
Vit B12
Oxidize very long chain of FA
Peroxisomes
RL enzyme of lipogenesis
Acetly coA carboxylase
RL enzyme of beta oxidation
Carnitine palmitoyl transferase
Location of lipogenesis
Cytosol
Location of Beta oxidation
Mitochondria
Citrate shuttle
Lipogenesis
Carnitine shuttle
Beta oidation
Condensation
Reduction
Dehydration
Reduction
Lipogenesis
Repetitive steps in Beta oxidation
OHOT
Oxidation
Hydration
Oxidation
THIOLYSIS
Product of lipogenesis
Palmitate
Product of beta oxidation
Acetyl coA
NADH
FADH2
Inhibitor of lipogenesis
Long chain fatty acly CoA
Inhibitor of Beta oxidation
Malonyl CoA
