Lipids Flashcards
Lipid classes
Fatty acids Triaglycerols Phospholipids Glycolipids Steroids
Triaglycerols
Dietary fuel and insulation (in adipose)
Lipid digestion and absorption
In small intestine by pancreatic enzymes (lipases) promoted by emulsification by bile salts and peristalsis
Lipid transportation
Free FA trsnsported through the blood in complex with serum albumin
Most FA esterified - carried in lipoproteins
TAGs and cholesterol cannot be transported as free molecules
Insoluble in water
Carnitine shuttle
Major site of regulation
CAT-1 inhibited by malonyl CoA
Prevents synthesis and degradation occurring simultaneously
Cholesterol
Component of cell membranes Precursor to other substances: Sterol hormones Vitamin D Bile acids
Ketone bodies
During fasting or starvation, [glucose] decreases
Excess acetyl CoA => ketone bodies
Can fuel brain cells during starvation
Formed in liver
Excessive ketones
Ketonaemia
Ketonuria
Acidaemia