Lipids 3 Flashcards
Where do we get FA’s?
- Diet
- Synthesis from excess carbs and proteins.
Where does FA synthesis occur in the body?
- Liver
- Lactating mammary gland
- Adipose tissue
Where does synthesis occur in the cell?
Cytosol
What are FA’s synthesis from?
Acetyl CoA.
Where is the acetyl CoA produced that is used to synthesise fatty acids?
Mitochondria
The citrate cycle occurs when what is in high concentration in the mitochondria?
Citrate
What 2 enzymes are required for FA synthesis?
- Acetyl CoA carboxylase
- FA synthase
What are the requirements?
- Acetyl CoA
- NADPH
What is the product?
Palmitic acid
What is acetyl CoA converted to at the start?
Malonyl CoA (this inhibits carnitine palmitoyl transferase 1 to stop synthesis and degradation occurring at the same time)
What is acetyl CoA carboxylase activated by?
- Citrate
- Insulin
What is acetyl CoA carboxylase deactivated by?
- Palmitoyl CoA
- Glucagon
- Epinephrine
What does malonyl CoA combine with in the elongation reaction?
Acetyl ACP
What happens after the elongation?
The reverse of FA degradation
What is used in this reverse reaction instead of NADH?
NADPH