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lipids 1 > lipids 2 > Flashcards

lipids 2 Flashcards

1
Q

it measures the total cholesterol in serum or plasma

A

enzymatic method

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2
Q

color development mixture liebermann burchardt reagent

A

glacial acetic acid
acetic anhydride
concentrated H2SO4

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3
Q

interferences in enzymatic measurement of total cholesterol

A

ascorbic acid
hemoglobin
bilirubin
plant sterols

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4
Q

It uses hexane extraction after hydrolysis with alcoholic KOH followed by reaction with Liebermann-Burchardt color reagent.

A

CDC Reference Method (Abell, Levy, and Brodie Method)

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5
Q

CDC Reference Method (Abell, Levy, and Brodie Method) end color

A

green

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6
Q

It is the highest order method for serum cholesterol developed by NIST

A

isotope dilution mass spectrometry

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7
Q

the gold standard method for cholesterol

A

isotope dilution mass spectrometry

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8
Q

isotope dilution mass spectrometry is developed by

A

NATIONAL INSTITUTE OF STANDARD AND TECHNOLOGY

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9
Q

NEUTRAL FAT

A

TRIGLYCERIDES/
TRIACYLGLYCEROL

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10
Q

t contains 3 molecules of fatty acid and one molecule of gLycerol by

A

TRIGLYCERIDES
ESTROGEN BOND

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11
Q

It is the main storage lipid in man (adipose tissue) - constitutes 95% of stored fat and the predominat form of glyceryl ester found in plasma.

A

TAG

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12
Q

fasting req of TAG

A

10-12 hrs

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13
Q

ref value TAG

A

< 150mg/dl

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14
Q

borderline high TAG

A

150-199 mg/dl

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15
Q

high tag

A

200-499 mg/dl

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16
Q

very high TAG

A

> 500 mg/dl

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17
Q

interference of TAG

A

ascorbic acid
bilirubin
hemolysis

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18
Q

TAG level increases to ___ betwen ___ yrs old

A

2 mg/dl/year
45-65

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19
Q

specific, rapid and easy to perform

A

enzymatic method

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20
Q

major interference of enzymatic method

A

glycerol

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21
Q

It involves hydrolysis of triglycerides to free fatty acids and glycerol, followed by the phosphorylation of glycerol to glycerophosphate.

A

Glycerol Kinase Method

22
Q

disappearance of NADH is measured at

A

340 nm

23
Q

Is a time-consuming manual method which cannot be automated.

A

modified van handel and zilversmith

24
Q

modified van handel and zilversmith end color

A

pink

25
Q

It involves alkaline hydrolysis (saponification) using alcoholic KOH, solvent extraction with chloroform

A

modified van handel and zilversmith

26
Q

The method measures total glycerides, which is defined as the sum of tri-, di, and monoglycerides plus any free glycerol.

A

GC-IDMS

27
Q

THE MOST HYDROPHOBIC LIPIDS

A

CHOLESTEROL ESTERS AND TRIGLYCERIDES

28
Q

In the endogenous pathway, production of TAG from FA by the liver take place, with synthesis of VLDL particles containing ____

A

apo B100 and apo E.

29
Q

considered to be an alternative pathway for HDL metabolism.

A

Cholesterol ester transfer protein

30
Q

hydrolyze TAG and cholesterol ester

A

lipoprotein lipase

31
Q

hydrolyze TAG and phospholipids from HDL

A

hepatic lipase

32
Q

catalyzes the esterification of cholesterol from HDL; enables HDL to
accumulate cholesterol as cholesterol ester.

A

Lecithin Cholestero! Acyl Transferase (LCAT) -

33
Q

hydrolyzes phospholipids and TAG in HDL.

A

Endothelial lipase -

34
Q

for efflux of cholesterol from peripheral cells into HDL

A

ATP-binding cassette protein A1 (ABCA1) -

35
Q

These are large macromolecular complexes of lipids

A

lipoproteins

36
Q

specialized proteins known as

A

apolipoproteins.

37
Q

To transport TAG and cholesterol to sites of energy storage and utilization

A

lipoproteins

38
Q

a fat-soluble vitamin) depends upon chylomicrons for absorption and relies upon VLDL and LDL for delivery to tissues.

A

vit. e

39
Q

It interacts with specific cell surface receptors and directs the lipids to the correct target organs and tissues in the body; present on the surface of lipoprotein particles.

A

apolipoprotein

40
Q

Major apolipoproteins:

A

ApoA-1, ApoB-48, and ApoB-100

41
Q

It is the largest and least dense of the lipoprotein particles.

A

chylomicrons

42
Q

major apolipo of chylomicrons

A

apoB-48

43
Q

density of chylomicrons

A

<0.95 kg/l

44
Q

it is secreted in the liver.* It transports endogenous TAG from the liver to muscle, fat depots, and peripheral tissues.

A

Pre-Beta Lipoprotein/Very-Low-Density Lipoprotein (VLDL)

45
Q

major apolipo of VLDL

A

apoB-100

46
Q

It is the smallest lipoproteins but the most dense (5-12 nm).
It is produced in the liver and intestine (nascent disk-shaped particles).

A

Alpha Lipoprotein /High Density Lipoprotein (HDL)

47
Q

It is synthesized in the liver.
It is the major end product from the catabolism of VLDL. MAJOR APOLIPO

A

Beta Lipoprotein/Low-Density Lipoprotein (LDL)
APO B-100

48
Q

It is a product of VLDL catabolism - “VLDL remnant.”

A

Intermediate Density Lipoprotein (IDL)
APOB-100

49
Q

It is similar to LDL (density and composition

A

LIPOPROTEIN (a)
apo (a)

50
Q

It is an abnormal lipoprotein found in obstructive jaundice and LCAT deficiency. it is a specific and sensitive indicator of cholestasis.

A

lipoprotein x
apoB-100 and apo (a)

lipids 1 (5 decks)

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