LipidChem Flashcards
Classification of lipids
siple lipids, complex lipids and precursor and derived lipids
simple lipids are made up of
esters of fatty acids + alcohols
Classifications of simple lipids
Fats and Waxes
main storage form of fats
Triacylglycerol
Classification of Simple lipids where in esters of fatty acids with higher molecular weight monohydric alcohol. A hdroxy group and a carboxyl group give rise to ester bond
Waxes
Classification of Lipids where in esters of fatty acids containing groups in addition to an alcohol and a fatty acid
Complex Lipids
Phospholipid is composed of ____
Fatty acid + Alcohol + Phosphoric Acid
Glycerophospholipid is composed of _____
Fatty acid + Glycerol + Phosphoric Acid
Sphingophospholipid is composed of ____
Fatty acid + Sphingosine + Phosphoric Acid
Glyceroglycolipids and Sphingoglycolipids are examples of _____
Glycolipids
Two divisions of sphingoglycolipids
Cerebroside and Ganglioside
Activated form of fatty acids on glcyerophospholipids are attached to what carbon numbers?
C1 and C2
What is attached to the 3rd Carbon atom of a Glycerophospholipid?
Phosphate Ester
Where can you find phophatidylethonolamine
Cell membrane
What is the other name for phosphatidylethonolamine
Cephaline
What is the most abundant phopsholipid in the cell membrane?
Phosphatidylcholine
What is Phosphatidylcholine’s also known as?
Lecithin
What phospholipid is a major constituent of pulmonary surfactant?
Phosphatidylcholine—dipalmitoyl Lecithin
The structural basis of the 2nd messenger of hormones (PIP2)
Phosphatidylinositol
enzyme that acts on Phosphatidylinositol 4,5-bisphosphate to form Diacylglycerol and Inositol triphosphate
Phospholipase C
2nd messenger products of phosphatidylinositol 4,5 bisphosphate
Diacylglycerol and Inositol Triphosphate
A phosphatidylglycerol that can be found only in the inner mitochondrial membrane that serves as a proton trap in oxidative phosphorylation
Cardiolipin (diphosphatidyl glycerol)
What is the other phospholipid other than Phosphatidylcohline that can be found in pulmonary surfactant
phosphatidylglycerol
What is the base of Sphingomyelin
Choline
Site and function of Sphingomyelin
Found in the myelin sheath and is important for cell signaling pathways
Difference between Glycerophospholipid and Sphingophospholipid
Sphingophospholipid has 1 FA and 1 Phosphate Ester; Glycerophospholipid has 2 FA and 1 Phosphate ester
Glycolipids are composed of
FA + Alcohol + Carbohydrate
Glycolipid that is found in weat flour
Flyceroglycolipid
Disease related B-Galactocerebroside
Krabbe’s disease
Disease related to B-Glucocerebroside
Gaucher’s diease
location of B-Galactocerebroside
Brain and myelin sheath
location of B-Glucocerebroside
Liver and spleen
A Sphingosine + FA is a ____
Ceramide
Glucose + Galactose + ceramide
GM3
GluGal + NacetylD-galactosamine
GM2
Glucose + Galactose + NAcetylD-galactosamine + Galactose
GM1
Enzyme related to Gangliosidosis
GM1-B-galactosidase
Disease related to hexaminidase A
Tasy Sach’s disease
Deficiency of Sulfolipid is associated with what?
Matachromatic leukodystrophy
Apoliproprotein in LDL
B100
Lipoprotein with B-48
Chylomicron
Lipoprotein with D
HDL
Carries exogenous TAG
Chylomicrons (B48)
representing a final stage in the catabolism of VLDL
LDL
derived from the liver for the export of triacylglycerol
VLDL
involved in cholesterol transport and VLDL and chylomicron metab
HDL
C atoms in a short Chain
2-4C
C atoms in a medium Chain
6-12C
C atoms in a Long chain
More than 12 C
The adjacent hydrogen group is at the same side of the double bond
Cis
The hydrogen group is at the opposite side of the double bound
Trans
why is B-hydroxybutyric acid not a real true ketone body
carbony carbon not attached to carbon instead to a carboxyl group
Vitamin for visual pigment
A
Vitamin for metabolism and growth
D
Vitamin for antioxidation
E
Vitamin for blood clotting factor
K
Pathway of lipid digestion
Stomach (lingual and gastric lipase) -> Duodenum -> Pancreatic lipase -> Intestinal lumen -> Liver
fates of glycerol
portal vein and phosphatidic acid pathway
Fates of Fatty Acid
heaptic portal vein as free fatty acid and triacylglcerol -> chylomicrons -> thoracic duct
Digestive Products
Free FA + 2monoacylglycerol + Cholesterol + Free FA