BETAOXIDATION Flashcards
The first three steps in beta oxidation is analogous to what other pathway?
CAC
In the Thiolase cleavage step, the two products are
Acetyl CoA and fatty acyl coA
ATPS in one molecule of Acetyl CoA
12
a-oxidation occurs in what site?
peroxisomes
How many Acetyl CoAs are consumed in the B-Oxidation of MSFA?
3 molecules of Acetyl CoA
Enzyme involved in the rate limiting step
Carnitine Acyl Transferase II
Inhibits Carnitine acyltransferase I
Malonyl CoA
What carbon number does a-oxidation act on?
C2/a-carbon
ATPs in one molecule of NADH
3
ATPS in one molecule of FADH2
2
What is propionyl CoA carboxylated into in odd beta oxidation?
methylmalonyl CoA
Main Reaction steps in Beta Oxidation
Oxidation, Hydration, Second Oxidation and Thiolytic Cleavage
In the formation of Methylmalonyl CoA, what enzyme is used?
Propionyl CoA carboxylase
where does w-oxidation occur?
endoplasmic reticulum
Final product of odd carbon beta oxidation
propionyl CoA
The number of chains there should be for it to utilize the mitochondrial transport
C12-C18
Shuttle system that transports fatty acids to the mitochondrial matrix
Carnitine Shuttle System
The pathway the acetyl coa from the cleavage step takes
Krebs Cycle
how many carbons are removed at a time in a-oxidation?
1 carbon atom
What step is skipped in the B-oxidation of MSFAs?
Acyl-CoA dehydrogenase step
Rate limiting step in B-oxidation
Formation of Fatty Acyl CoA from acyl cartnitine as it is transported across the mitochondrial membrane to the mitochondrial matrix
products of odd carbon beta oxidation when the 5 carbon acyl coa is cleaved
1 molecule of C3 propionyl CoA and 1 molecule of c2 acetyl CoA
Methylmalonyl CoA is turned into Succinyl CoA through through what factors
racemace, isomerase, vitamin b12
Glucagon’s effect on Beta oxidation
increases rate of Beta-Oxidation
Enzyme present in the cytosol as Fatty acid is turned into Fatty Acyl CoA
Fatty Acyl coA synthase/ thiokinase
Insulin’s effect on Beta-oxidation
decreases rate of Beta-Oxidation
What carbon number does b-oxidation act on?
C3
Site of Beta oxidation
Mitochondrial Matrix
