Lipid Lowering Drugs Flashcards

1
Q

What types of lipids are there?

A
  • cholesterol
  • triglycerides
  • fatty acids
  • phospholipids
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2
Q

LDL, HDL

A

want low LDL and high HDL

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3
Q

why do we want to lower cholesterol?

A

-reduction in vascular events

  • decrease cvs mortality, cvs morbitiy
  • clear relationship in lower cholesterol and reducing cardiovascular events
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4
Q

Who do we treat with statins

A
  • people with angina, MI, cva,
  • diabetics
  • CVS risk is over 30% over 10 years
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5
Q

How low do we lower LDL

A
  • we dont know?

- also do life style changes, drugs

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6
Q

Simvastatin

A

statin - lower TC, LDL and increase HDL and decrease triglyertide
-blocks acetyl choline going to cholesterol

adverse effects - skeletal muscle aches and pains
-also interacts with other drugs - verapamil, amiodarone, diltiazem, erythromycin - p450 cytochrome

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7
Q

Bexafibrate

A
  • decreases triglycerides, increase HDL
  • Should try all of this first before going on this - diet, exercise, weight loss, decrease alcohol, increase DM control , but if still have high triglycerides then can use this
  • combined therapy with statins - resistant hyperchlesterolaemia
  • decrease VLDL production
  • gi upset, muscle problems
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8
Q

Ezetimbe

A
  • blocks transporter in intestinal mucosa
  • decraese cholesteorl absorption
  • lower intrahepatocyte choelsterol

side efects - abdominal pain, diahorrhea

-normally used if person on a statin, but want to improve ldl reduction further

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9
Q

Nicotinic acid

A
  • not very commonly used
  • only if want to bring down triglycerides
  • dry skin, gi intolerance, flushing
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