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MOHD3: Exam 2 > Lipid Lowering Drugs > Flashcards

Lipid Lowering Drugs Flashcards

1
Q

cholestyramine

A

Bile Acid Sequestrant - first generation - didn’t taste good
Prevent intestinal absorption of bile
Up-regulate LDL receptors (decrease LDL)
Increase hepatic production of VLDL –> increases triglycerides a bit
Can be used to reduce hyperglycemia

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2
Q

cholestyramine

A 
Bile Acid Sequestrant - first generation
Prevent intestinal absorption of bile 
Up-regulate LDL receptors
Increase hepatic production of VLDL --> increases triglycerides a bit
Can be used to reduce hyperglycemia
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3
Q

colesevelam

A

Bile Acid Sequestrant - second generation
Prevent intestinal absorption of bile
Up-regulate LDL receptors
Increase hepatic production of VLDL –> increases triglycerides a bit
Can be used to reduce hyperglycemia

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4
Q

colesevelam

A

Bile Acid Sequestrant - second generation - pill
Prevent intestinal absorption of bile
Up-regulate LDL receptors
Increase hepatic production of VLDL –> increases triglycerides a bit
Can be used to reduce hyperglycemia

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5
Q

Nicotinic Acid=Niacin

A

Inhibit VLDL secretion –> decrease LDL production
Increase HDL
decrease triglycerides
Toxicities: long term my increase insulin resistance, hyperuricemia cuz niancin competes with uric acid for excretion, prostaglandin mediated vasodilation –> blunt this with NSAIDs, liver issues

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6
Q

lovastatin

A

HMG CoA reductase Inhibitor: competitively inhibit to lower cholesterol synthesis and upregulate LDL receptors (decrease LDL)

CYP3A4
prodrug

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7
Q

simvastatin

A

HMG CoA reductase Inhibitor: competitively inhibit to lower cholesterol synthesis and upregulate LDL receptors (decrease LDL)

CYP3A4
prodrug

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8
Q

atrovastatin

A

HMG CoA reductase Inhibitor: competitively inhibit to lower cholesterol synthesis and upregulate LDL receptors (decrease LDL)

CYP3A4
prodrug

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9
Q

fluvastatin

A

HMG CoA reductase Inhibitor: competitively inhibit to lower cholesterol synthesis and upregulate LDL receptors (decrease LDL)

CYP2C9
active

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10
Q

provastatin

A

HMG CoA reductase Inhibitor: competitively inhibit to lower cholesterol synthesis and upregulate LDL receptors (decrease LDL)

CYP2C9
active

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11
Q

gemfibrozil

A

Fibric Acid
Upregulate lipoprotein lipase –> Decrease trigycerides (VLDVL)
Increase HDL
Slight Increase LDL

Increase blood concentration of most statins

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12
Q

clofibrate

A

Upregulate lipoprotein lipase –> Decrease trigycerides (VLDVL)
Increase HDL
Slight Increase LDL

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13
Q

fenofibrate

A

Upregulate lipoprotein lipase –> Decrease trigycerides (VLDVL)
Increase HDL
Slight Increase LDL

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14
Q

ezetimibe

A

Inhibit intestinal cholesterol absorption

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MOHD3: Exam 2 (6 decks)

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