Anti-arrhythmia drugs

Question 1

quinidine

Answer 1

Class Ia: Na+ blockers - prolong QT
use for Brugade Syndrome, Early Repolarization Syndrome
Liver metabolism

Question 2

procainamide

Answer 2

Class Ia: Na+ blockers - prolong QT
acute use
renal metabolism

Question 3

disopyramide

Answer 3

Class Ia: Na+ blockers - prolong QT
vagolytic
renal metabolism
causes urinary retention (prostate contract)  in older men so use it more for women 
dry mouth

Question 4

lidocaine

Answer 4

Class Ib - shorten QT
IV, acute
Liver metabolism

Question 5

mexilitene

Answer 5

Class Ib - shorten QT
"oral lidocaine" 
Liver metabolism
use for automatic arrhythmias
take with meals

Question 6

propafanone

Answer 6

Class Ic: Na blockers, use dependent
Treat Afib in women
Can raise INR - make Warfarin more effective
Liver met

Question 7

propafanone

Answer 7

Class Ic: Na blockers, use dependent
Treat Afib in women
Can raise INR - make Warfarin more effective
Liver met

Question 8

fecainide

Answer 8

Class Ic: Na blockers, use dependent
NOT for Atrial Flutter, not for CHF or CAD
mostly renal metabolism
good for mostly healthy ppl

Question 9

Sotolol

Answer 9

Class III: K+ blocker if use >80mg

(@

Question 10

dofetilide

Answer 10

Class III: K+ blocker

must be started in hospital

Question 11

dronedarone

Answer 11

Class III: K+ blocker

Use only in paroxismal A. fib because its not as potent as amiodarone

Question 12

amioderone

Answer 12

Has Class I, II, III and Ca+ blocking properties
best drug for A. fib
predictable toxicities

Question 13

ranolazine

Answer 13

Na, K, Ca channel blocking properties

in trials for arrhythmia treatment, developed as anti-anginal drug