Lipid Lowering Agents

Question 1

STATINS. A.P.Lovas
🏂: ⬇️⬇️⬇️LDL. ⬆️ HDL.
⬇️ Trigly
🚫HMG CoA ▶️ mevalonate

🙅🏻: 🏈 ⚠️💪🏼 😰 (with fibrates and niacin)

Answer 1

MOA: HMG CoA reductase inhibitors
Inhibits conversion of HMG- CoA to mevalonate.

SE: hepatotoxicity, myopathy
Pravastatin
Lovas
Ator

Question 2

BILE ACID RESINS

CHOLE’s cole’s

🏂: ❌🐍👅 of 🐸
🙅🏻: 🐍😰🚽

Answer 2

Cholestyramine
Colestipol
Colesevelam

MOA: Prevents intestinal reabsorption of bile acids; so liver must use more cholesterol to make more.
SE: GI upset, decrease absorption other drugs and fat soluble vitamins.

Question 3

EZETIMIBE

❌ 🍤👅🖌🐍
⬇️LDL
⬆️🏈🚽

Answer 3

MOA: Prevent cholesterol absorption at the small intestine brush border

Decrease LDL

SE: increased LFTs and diarrhea

Question 4

FIBRATES Gemi, besa a feno

⬇️LDL. ⬆️ HDL ⬇️⬇️⬇️ Trigly

😃 PPAR ➰➡️ HDL 🔂
🆙regulate LDL▶️ ⬆️TG🚽

SE: 💪🏼 😰, 🍤 ⛈🌰

Answer 4

MOA: upregulates LPL, this increase Triglycerates clearance. Inhibits cholesterol 7➰hydroxylase this ⬇️ bile acid synthetisis, decreasing cholesterol solubility ➡️⬆️ gallstone production.
Activates PPAR alpha to induce HDL synthesis
SE:Myopathy
Cholesterol gallstones

Question 5

NIACIN
🏂:🅱3️⃣
❌🍤🚫 in AT, ⬇️🏈 VLDL 🔄

🙅🏻: 😳,👍🏼🍬, ⬆️ U⚡️⚡️

Answer 5

MOA: Inhibits lipolysis (hormone sensitive lipase) in adipose tissue

Reduces hepatic VLDL synthesis

SE: red, flushing face
Hyperglycemia
Hyperuricemia