Diabetes Drugs

Question 1

BIGUANIDES

🏂:
⬇️ 🍬neogenesis 🏈
⬆️ 🍬lysis🏈
⬆️🛣 🍬🆙 take

🙅🏻:🍶🍋
🏈ℹ️
🍣ℹ️

Answer 1

Metformin

MOA: Decrease gluconeogenesis
Increase glycolysis
Increase peripheral glucose uptake

SE: lactic acidosis
Contraindicated in liver and renal insufficiency.

Question 2

SULFONYLUREAS

🏂: 🙏🏼🍌📺 in 🐠📱
⬆️📈Ca+👉🏼💉 release

🙅🏻: 👎🏼🍬 2nd Gen.— Chlo-tol
disulfiram 👍🏼 Sx 1st Gen. — 3Gly’s

Answer 2

1st Generation 
CHLORPROPAMIDE
TOLBUTAMIME 
2nd generation Gly's
GLIMEPIRIDE
GLIPIZIDE
GLYBURIDE
 MOA: Close K+ channels in B cells membrane, cell depolarizes, insulin release via Ca+ influx
SE: hypoglycemia 
       Disulfiram like syndrome

Question 3

THIAZOLIDINEDIONES/ glitazones
Tios:
Pio y rosi gritan zona

🏂: Fuman🚬 pipa que Esta en 🏈 and 🧀
⬆️GLU GLU 4️⃣

🙅🏻 : 🏈⚠️, 💔 ,

Answer 3

Pioglitazone
Rosiglitazone

MOA: increase insulin sensitivity in peripheral tissues.
Binds to PPAR gamma nuclear transcription regulator.
PPAR (liver and adipose tissue)
increased expression of GLUT4
SE: hepatotoxicity, Heart failure

Question 4

MEGLITINIDES. Reparate…REPA/NATE

🏂: 🍜😋💉 by binding to 🍌📺 on 🐠📱

🙅🏻: 👎🏼🍬

Answer 4

Nateglinide
Repaglinide

MOA: stimulates postprandial insulin release by binding to K+ channels on B cell membranes

SE: hypoglycemia

Question 5

Alpha GLUCOSIDASE INHIBITORS

🏂: ❌🐍🖌➰ glucosidases
⏳ 🍞 💧 and 🍬 👅
⬇️ 😋🍜👍🏼🍬

🙅🏻: 🐍🚽🤒

Answer 5

ACARBOSE
MIGLITOL

MOA:Inhibit intestinal brush border a-glucosidases.
Delayed carbohydrate hydrolysis and glucose absorption.
Decrease postprandial hyperglycemia

SE: GI disturbances

Question 6

GLP-1 analogs

Answer 6

EXENATIDE
LIRAGLUTIDE (💉)

MOA: increase glucose dependent insulin release, decrease glucagon release, decrease gastric emptying, increase satiety.

SE: nausea, vomiting, pancreatitis.