Lipid Lowering Agents

Question 1

What is the MOA of cholesterol–synthesis inhibitors ?

Answer 1

Interferes with cholesterol synthesis
Inhibits hepatic HMG COA, reductase (enzyme), causes hepatocytes to synthesize more LDH receptors
–therefore more LDL is removed

Question 2

What are cholesterol synthesis inhibitors used for ?

Answer 2

Primarily to lower LDL (dose dependent)

Also decreases VLDL, increases HDL

Question 3

Side effects & nursing implications of cholesterol–synthesis inhibitors

Answer 3

Side effects:
Few GI, headaches, rash, muscle wasting, weakness

NI: check LFTs
Admin. In evening
Effects are seen in 2 weeks, full effects seen in 4 weeks

Question 4

Examples of cholesterol–synthesis inhibitors

Answer 4

(Statins)

Lovastatin
Simvastatin

Question 5

What is the most effective lipid lowering agent

Answer 5

Cholesterol– synthesis inhibitors